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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hcfc2
host cell factor C2
MGI:1915183
41 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hcfc2em1(IMPC)Ccpcz/Hcfc2em1(IMPC)Ccpcz
C57BL/6NCrl-Hcfc2em1(IMPC)Ccpcz/Ccpcz 		abnormal adrenal gland morphology J:211773
abnormal bone structure J:211773
abnormal cranium morphology J:211773
abnormal fibula morphology J:211773
abnormal heart morphology J:211773
abnormal liver morphology J:211773
abnormal pancreas morphology J:211773
abnormal pelvic girdle bone morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
decreased CD8-positive, naive alpha-beta T cell number J:211773
decreased liver weight J:211773
decreased lymphocyte cell number J:211773
decreased spleen weight J:211773
enlarged heart J:211773
enlarged thymus J:211773
increased CD4-positive NK T cell number J:211773
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating bilirubin level J:211773
increased circulating calcium level J:211773
increased circulating iron level J:211773
increased fasting circulating glucose level J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
increased memory-marker CD4-positive NK T cell number J:211773
small liver J:211773
small spleen J:211773
thrombocytopenia J:211773
Hcfc2em1Btlr/Hcfc2em1Btlr
C57BL/6J-Hcfc2em1Btlr 		decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2+
involves: C57BL/6J 		decreased interferon-beta secretion J:251008
decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2fkls
C57BL/6J-Hcfc2fkls 		abnormal innate immunity J:94077
Hcfc2fkls/Hcfc2fkls
involves: C57BL/6J 		decreased circulating interferon-alpha level J:251008
decreased circulating interferon-beta level J:251008
decreased interferon-beta secretion J:251008
decreased tumor necrosis factor secretion J:251008
increased susceptibility to Herpesvirales infection J:251008
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:251008
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:251008
Hcfc2fkls/Hcfc2min
involves: C57BL/6J 		decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2sca
involves: C57BL/6J 		decreased tumor necrosis factor secretion J:251008
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory