Hcfc2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcfc2
host cell factor C2
MGI:1915183

8 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcfc2^em1Btlr/Hcfc2^em1Btlr C57BL/6J-Hcfc2^em1Btlr	decreased tumor necrosis factor secretion	J:251008
Hcfc2^fkls/Hcfc2⁺ involves: C57BL/6J	decreased interferon-beta secretion	J:251008
Hcfc2^fkls/Hcfc2⁺ involves: C57BL/6J	decreased tumor necrosis factor secretion	J:251008
Hcfc2^fkls/Hcfc2^fkls C57BL/6J-Hcfc2^fkls	abnormal innate immunity	J:94077
Hcfc2^fkls/Hcfc2^fkls involves: C57BL/6J	decreased circulating interferon-alpha level	J:251008
	decreased circulating interferon-beta level	J:251008
	decreased interferon-beta secretion	J:251008
	decreased tumor necrosis factor secretion	J:251008
	increased susceptibility to Herpesvirales infection	J:251008
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:251008
	increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality	J:251008
Hcfc2^fkls/Hcfc2^min involves: C57BL/6J	decreased tumor necrosis factor secretion	J:251008
Hcfc2^fkls/Hcfc2^sca involves: C57BL/6J	decreased tumor necrosis factor secretion	J:251008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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