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Ppap2b
Gene Detail
Symbol

Name
ID
Ppap2b
phosphatidic acid phosphatase type 2B
MGI:1915166
Synonyms
1110003O22Rik, D4Bwg0538e, D4Bwg1535e, Lpp3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
49.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:105157347-105232764 bp, + strand
From VEGA annotation of GRCm38

  75418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPAP2B
Protein SuperFamily: Lipid phosphate phosphohydrolase 3
Gene Tree: Ppap2b

Human
homologs
PPAP2B, phosphatidic acid phosphatase type 2B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8613
neXtProt AC: NX_O14495

Human Synonyms: Dri42, LPP3, PAP2B, VCIP

Human Chr (Location): 1p32.2; chr1:56494747-56579584 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(79) : Gene trapped(71) Targeted(8)
Genomic Mutations involving Ppap2b (1)
Incidental mutations (data from CvDC )
 
Homozygous mutant mice do not survive past E10.5 and show defects in extraembryonic vasculogenesis and axis patterning.
 
Interactions
Ppap2b interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process Bergmann glial cell differentiation, blood vessel development, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (504)    Tissues (252)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 350
In situ reporter (knock in) 137
cDNA source data(129)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppap2b    NEW 
Molecular
reagents
All nucleic(134) cDNA(132) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008128 (Evidence)
Ensembl Gene Model ENSMUSG00000028517 (Evidence)
Entrez Gene 67916 (Evidence)
UniGene 348326
DFCI TC1576144, TC1603655, TC1609182, TC1685288
DoTS DT.101223411, DT.110833668, DT.533602
NIA Mouse Gene Index U004576
EC 3.1.3.4
Consensus CDS Project CCDS18417.1
International Mouse Phenotyping Consortium Status Ppap2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008128 VEGA Gene Model | MGI Sequence Detail 75418 C57BL/6J ±  kb
transcript OTTMUST00000018472 VEGA | MGI Sequence Detail 3159 Not Applicable 
polypeptide OTTMUSP00000008487 VEGA | MGI Sequence Detail 312 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(747 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Protein Ontology PR:000013052 lipid phosphate phosphohydrolase 3
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:222906 Panchatcharam M, et al., Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):837-45
All references(54)
Other
accession IDs
MGD-MRK-34207, MGD-MRK-35800, MGI:106513, MGI:107334, MGI:1915698, MGI:2140515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory