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Tmem70 Gene Detail
Summary
  • Symbol
    Tmem70
  • Name
    transmembrane protein 70
  • Synonyms
    1110020A09Rik, 2210416J16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915068
    NCBI Gene: 70397
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16665207-16678275 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 5.10 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915068
protein coding gene Chr1:16665191-16678275 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015858
protein coding gene Chr1:14177841-14191527 (+)
A/J MGP_AJ_G0015839
protein coding gene Chr1:13992780-14007155 (+)
AKR/J MGP_AKRJ_G0015798
protein coding gene Chr1:14021959-14038430 (+)
BALB/cJ MGP_BALBcJ_G0015795
protein coding gene Chr1:13728512-13747605 (+)
C3H/HeJ MGP_C3HHeJ_G0015629
protein coding gene Chr1:14059018-14076001 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016249
protein coding gene Chr1:14794300-14808682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013970
protein coding gene Chr1:12604243-12617073 (+)
CAST/EiJ MGP_CASTEiJ_G0015210
protein coding gene Chr1:14133797-14148403 (+)
CBA/J MGP_CBAJ_G0015602
protein coding gene Chr1:15146877-15168379 (+)
DBA/2J MGP_DBA2J_G0015701
protein coding gene Chr1:13601565-13616100 (+)
FVB/NJ MGP_FVBNJ_G0015706
protein coding gene Chr1:13389426-13402879 (+)
LP/J MGP_LPJ_G0015773
protein coding gene Chr1:14384861-14398687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015725
protein coding gene Chr1:15762397-15778881 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016296
protein coding gene Chr1:13989163-14004466 (+)
PWK/PhJ MGP_PWKPhJ_G0014994
protein coding gene Chr1:13375926-13389325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014775
protein coding gene Chr1:14181579-14194300 (+)
WSB/EiJ MGP_WSBEiJ_G0015273
protein coding gene Chr1:13917313-13931222 (+)



Homology
more
  • Human Ortholog
    TMEM70, transmembrane protein 70
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM70, transmembrane protein 70
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MC5DN2
  • Links
    NCBI Gene ID: 54968
    neXtProt AC: NX_Q9BUB7
    UniProt: Q9BUB7

  • Chr Location
    8q21.11; chr8:73976142-73982783 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TMEM70 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality during organogenesis associated with severe growth delay, impaired biosynthesis and assembly of ATP synthase, decreased ATP production, oxidative stress, delayed heart development, and altered mitochondrial ultrastructure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025940 Ensembl Gene Model | MGI Sequence Detail 13069 C57BL/6J ±  kb
    transcript ENSMUST00000177501 Ensembl | MGI Sequence Detail 1636 Not Applicable  
    polypeptide ENSMUSP00000135483 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR009724 TMEM70 family
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 82

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917647
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:238642 Vrbacky M, et al., Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet. 2016 Nov 01;25(21):4674-4685

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory