About   Help   FAQ
Dgat2
Gene Detail
 Symbol
Name
ID
Dgat2
diacylglycerol O-acyltransferase 2
MGI:1915050
Synonyms 0610010B06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.01 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99153663-99182713 bp, - strand
From NCBI annotation of GRCm38

  29051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 2-acylglycerol O-acyltransferase 1
Gene Tree: Dgat2

Human
homologs
Human Homolog DGAT2, diacylglycerol O-acyltransferase 2
NCBI Gene ID 84649
neXtProt AC  NX_Q96PD7
Human Synonyms  ARAT, GS1999FULL
Human Chr (Location)  11q13.5; chr11:75768733-75801536 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die shortly after birth due to inadequate substrates for energy and impaired skin barrier function leading to dehydration.
 
Phenotype Images(3)
Interactions
Dgat2 interacts with 153 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cellular response to oleic acid, cellular triglyceride homeostasis, ...
Component cell, endoplasmic reticulum, ...
Function 2-acylglycerol O-acyltransferase activity, diacylglycerol O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (162)    Tissues (111)    Images (37)
Theiler Stages: 15, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 146
RT-PCR 16
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030747 (Evidence)
Entrez Gene67800 (Evidence)
DFCITC1574195
NIA Mouse Gene IndexU028891
EC2.3.1.20, 2.3.1.76
Consensus CDS ProjectCCDS21477.1
International Mouse Knockout Project StatusDgat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 67800 NCBI Gene Model | MGI Sequence Detail 29051 C57BL/6J ±  kb
transcript NM_026384 RefSeq | MGI Sequence Detail 2251 C57BL/6 
polypeptide Q9DCV3 UniProt | EBI | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(351 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007130 Diacylglycerol acyltransferase
Protein Ontology PR:000006433 diacylglycerol O-acyltransferase 2
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211139 Sheng L, et al., Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice. PLoS One. 2013;8(12):e83269
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory