Dgat2
Gene Detail

Symbol Name ID

Dgat2 diacylglycerol O-acyltransferase 2 MGI:1915050

Synonyms

0610010B06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.01 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:99153663-99182713 bp, - strand From NCBI annotation of GRCm38   29051 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Dgat2 ± 2 cM)

Protein SuperFamily: 2-acylglycerol O-acyltransferase 1
Gene Tree: Dgat2

Human ortholog

DGAT2 diacylglycerol O-acyltransferase 2 NCBI Gene ID 84649
Human Synonyms: ARAT, GS1999FULL
Human Chr11:75479778-75512579 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutant mice die shortly after birth due to inadequate substrates for energy and impaired skin barrier function leading to dehydration.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	cellular response to oleic acid, cellular triglyceride homeostasis, ...
Component	endoplasmic reticulum, integral to endoplasmic reticulum membrane, ...
Function	2-acylglycerol O-acyltransferase activity, diacylglycerol O-acyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (110)    Images (37)
Theiler Stages: 15, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	146
RT-PCR	16

cDNA source data(179)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(181) cDNA(179) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030747 (Evidence)
Entrez Gene	67800 (Evidence)
UniGene	180189
DFCI	TC1574195
NIA Mouse Gene Index	U028891
EC	2.3.1.20, 2.3.1.76
Consensus CDS Project	CCDS21477.1
International Mouse Knockout Project Status	Dgat2

Sequences

Length	Strain/Species
genomic	67800	NCBI Gene Model | MGI Sequence Detail	29051	C57BL/6J
transcript	NM_026384	RefSeq | MGI Sequence Detail	2251	C57BL/6
polypeptide	Q9DCV3	UniProt | EBI | MGI Sequence Detail	388	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(146 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007130	Diacylglycerol acyltransferase
Protein Ontology	PR:000006433	diacylglycerol O-acyltransferase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190740 Xu N, et al., The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol. 2012 Sep 3;198(5):895-911
All references(42)