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Wfdc2 Gene Detail
Summary
  • Symbol
    Wfdc2
  • Name
    WAP four-disulfide core domain 2
  • Synonyms
    1600023A02Rik, HE4, WAP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914951
    NCBI Gene: 67701
  • Gene Overview
    MyGene.info: WFDC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164562561-164568510 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.20 cM, cytoband H3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914951
protein coding gene Chr2:164562413-164568510 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026857
protein coding gene Chr2:170017741-170023835 (+)
A/J MGP_AJ_G0026823
protein coding gene Chr2:163094462-163100556 (+)
AKR/J MGP_AKRJ_G0026794
protein coding gene Chr2:167934995-167941089 (+)
BALB/cJ MGP_BALBcJ_G0026832
protein coding gene Chr2:163455157-163461251 (+)
C3H/HeJ MGP_C3HHeJ_G0026574
protein coding gene Chr2:168291465-168297562 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027280
protein coding gene Chr2:174958653-174964750 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024650
protein coding gene Chr2:156499188-156505325 (+)
CAST/EiJ MGP_CASTEiJ_G0026034
protein coding gene Chr2:168719631-168725964 (+)
CBA/J MGP_CBAJ_G0026551
protein coding gene Chr2:181292562-181298656 (+)
DBA/2J MGP_DBA2J_G0026689
protein coding gene Chr2:162264121-162270237 (+)
FVB/NJ MGP_FVBNJ_G0026655
protein coding gene Chr2:160682867-160689609 (+)
LP/J MGP_LPJ_G0026792
protein coding gene Chr2:170102352-170108446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026675
protein coding gene Chr2:184874005-184880099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027336
protein coding gene Chr2:167837759-167845190 (+)
PWK/PhJ MGP_PWKPhJ_G0025771
protein coding gene Chr2:161859232-161865536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025572
protein coding gene Chr2:166727538-166734382 (+)
WSB/EiJ MGP_WSBEiJ_G0026105
protein coding gene Chr2:168709122-168715282 (+)



Homology
more
  • Human Ortholog
    WFDC2, WAP four-disulfide core domain 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    WFDC2, WAP four-disulfide core domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ461P17.6, EDDM4, HE4, WAP5
  • Links
    NCBI Gene ID: 10406
    neXtProt AC: NX_Q14508
    UniProt: Q14508

  • Chr Location
    20q13.12; chr20:45469754-45481532 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67701 NCBI Gene Model | MGI Sequence Detail 5950 C57BL/6J ±  kb
transcript NM_026323 RefSeq | MGI Sequence Detail 708 C57BL/6  
polypeptide Q9DAU7 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 71
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:202352 Boualia SK, et al., A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory