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Patl2 Gene Detail
Summary
  • Symbol
    Patl2
  • Name
    protein associated with topoisomerase II homolog 2 (yeast)
  • Synonyms
    4930424G05Rik, Pat1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914828
    NCBI Gene: 67578
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122120108-122186189 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.53 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    501 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914828
protein coding gene Chr2:122120103-122186189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026405
protein coding gene Chr2:125102023-125175213 (-)
A/J MGP_AJ_G0026367
protein coding gene Chr2:119992322-120058663 (-)
AKR/J MGP_AKRJ_G0026344
protein coding gene Chr2:123350795-123422619 (-)
BALB/cJ MGP_BALBcJ_G0026379
protein coding gene Chr2:120217276-120293958 (-)
C3H/HeJ MGP_C3HHeJ_G0026124
protein coding gene Chr2:123839886-123908122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026826
protein coding gene Chr2:129165298-129236910 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024205
protein coding gene Chr2:114964291-115032726 (-)
CAST/EiJ MGP_CASTEiJ_G0025586
protein coding gene Chr2:124167051-124243887 (-)
CBA/J MGP_CBAJ_G0026103
protein coding gene Chr2:133720413-133793555 (-)
DBA/2J MGP_DBA2J_G0026240
protein coding gene Chr2:119388559-119458163 (-)
FVB/NJ MGP_FVBNJ_G0026202
protein coding gene Chr2:118179861-118247916 (-)
LP/J MGP_LPJ_G0026342
protein coding gene Chr2:125351638-125428421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026222
protein coding gene Chr2:137925932-138003187 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026881
protein coding gene Chr2:123465265-123539164 (-)
PWK/PhJ MGP_PWKPhJ_G0025322
protein coding gene Chr2:118999530-119067764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025122
protein coding gene Chr2:122608373-122678957 (-)
WSB/EiJ MGP_WSBEiJ_G0025658
protein coding gene Chr2:124325499-124396122 (-)



Homology
more
  • Human Ortholog
    PATL2, PAT1 homolog 2
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PATL2, PAT1 homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hPat1a, OOMD4, Pat1a
  • Links
    NCBI Gene ID: 197135
    neXtProt AC: NX_C9JE40
    UniProt: C9JE40

  • Chr Location
    15q21.1; chr15:44665732-44711389 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Patl2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027233 Ensembl Gene Model | MGI Sequence Detail 66082 C57BL/6J ±  kb
transcript ENSMUST00000028665 Ensembl | MGI Sequence Detail 2434 Not Applicable  
polypeptide ENSMUSP00000028665 Ensembl | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:264835 Christou-Kent M, et al., PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice. EMBO Mol Med. 2018 May;10(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory