Slc39a8 MGI Mouse Gene Detail - MGI:1914797 - solute carrier family 39 (metal ion transporter), member 8

Symbol

Slc39a8
Name

solute carrier family 39 (metal ion transporter), member 8
Synonyms

4933419D20Rik, BIGM103, ZIP8

Feature Type

protein coding gene
IDs

MGI:1914797
NCBI Gene: 67547
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr3:135825279-135888572 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 63.04 cM
Mapping Data

3 experiments

SNPs within 2kb

545 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914797	protein coding gene	Chr3:135816884-135888572 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027910	protein coding gene	Chr3:138746408-138814451 (+)
A/J	MGP_AJ_G0027868	protein coding gene	Chr3:133867259-133932343 (+)
AKR/J	MGP_AKRJ_G0027833	protein coding gene	Chr3:137405556-137477004 (+)
BALB/cJ	MGP_BALBcJ_G0027881	protein coding gene	Chr3:133701255-133763876 (+)
C3H/HeJ	MGP_C3HHeJ_G0027610	protein coding gene	Chr3:137748540-137814340 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028324	protein coding gene	Chr3:143589610-143656229 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025662	protein coding gene	Chr3:129079011-129144866 (+)
CAST/EiJ	MGP_CASTEiJ_G0027066	protein coding gene	Chr3:137478945-137561287 (+)
CBA/J	MGP_CBAJ_G0027586	protein coding gene	Chr3:148422823-148501985 (+)
DBA/2J	MGP_DBA2J_G0027726	protein coding gene	Chr3:133012921-133082939 (+)
FVB/NJ	MGP_FVBNJ_G0027693	protein coding gene	Chr3:130501785-130570662 (+)
LP/J	MGP_LPJ_G0027836	protein coding gene	Chr3:140167118-140234948 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027724	protein coding gene	Chr3:156532162-156604793 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028382	protein coding gene	Chr3:136945198-137015497 (+)
PWK/PhJ	MGP_PWKPhJ_G0026790	protein coding gene	Chr3:132735899-132804616 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026616	protein coding gene	Chr3:135027623-135097169 (+)
WSB/EiJ	MGP_WSBEiJ_G0027145	protein coding gene	Chr3:137737034-137810964 (+)

Human Ortholog

SLC39A8, solute carrier family 39 member 8

Vertebrate Orthologs

11

Human Ortholog

SLC39A8, solute carrier family 39 member 8
Orthology source: HomoloGene, HGNC
Synonyms

BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8
Links

HGNC:20862

NCBI Gene ID: 64116

neXtProt AC: NX_Q9C0K1

UniProt: Q9C0K1
Chr Location

4q24; chr4:102251041-102345498 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11155
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC39A8
Gene Tree

Slc39a8

Diseases

1 with Slc39a8 mouse models; 1 with human SLC39A8 associations

Human Disease

Mouse Models

left ventricular noncompaction

IDs

View 1 model

congenital disorder of glycosylation type IIn

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Slc39a8
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

333
Tissues

87
cDNA Data

16
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a8

ZFIN slc39a8

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Slc39a8 interacts with 236 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

61
RefSeq

12
UniProt

1
CCDS

CCDS17859.1

Ensembl

ENSMUSG00000053897 (Evidence)
NCBI Gene

67547

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053897	Ensembl Gene Model \| MGI Sequence Detail	63294	C57BL/6J	± kb
transcript	ENSMUST00000167390	Ensembl \| MGI Sequence Detail	3533	Not Applicable
polypeptide	ENSMUSP00000128245	Ensembl \| MGI Sequence Detail	462	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015135 zinc transporter ZIP8

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 23

cDNA 19

Primer pair 4

Microarray probesets 5

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MGI:2139613

Summaries

All 55

Developmental Gene Expression 10

Diseases 2

Gene Ontology 5

Phenotypes 18
Earliest

J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
Latest

J:273396 Liu L, et al., Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation. Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G569-G579

TSS for Slc39a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31848	Chr3:135825605-135825620 (+)	334 bp
Tssr31849	Chr3:135825648-135825664 (+)	377 bp
Tssr31850	Chr3:135825788-135825800 (+)	515 bp
Tssr31851	Chr3:135826075-135826086 (+)	802 bp
Tssr31852	Chr3:135826095-135826118 (+)	828 bp
Tssr31853	Chr3:135826128-135826173 (+)	872 bp
Tssr31854	Chr3:135826228-135826243 (+)	957 bp
Tssr31855	Chr3:135826251-135826270 (+)	982 bp
Tssr31856	Chr3:135826275-135826329 (+)	1,023 bp
Tssr31857	Chr3:135826385-135826420 (+)	1,124 bp
Tssr31858	Chr3:135826423-135826449 (+)	1,157 bp
Tssr31861	Chr3:135887073-135887093 (+)	61,804 bp
Tssr31862	Chr3:135887196-135887211 (+)	61,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14