Symbol
Name
ID

Slc39a8
solute carrier family 39 (metal ion transporter), member 8
MGI:1914797

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased activity of mitochondrial complex II	Decreased activity of mitochondrial complex IV	Decreased activity of the pyruvate dehydrogenase complex	Hypomanganesemia	Abnormal blood zinc concentration	Increased CSF lactate	Type II transferrin isoform profile
Disease(s) Associated with SLC39A8
congenital disorder of glycosylation type IIn

Mouse Phenotypes

homeostasis/metabolism phenotype

increased insulin secretion

abnormal homeostasis

decreased circulating glucose level

increased circulating glucose level

increased circulating insulin level

increased circulating triglyceride level

increased circulating phosphate level

edema

increased urine glucose level

insulin resistance

abnormal zinc level

decreased brain zinc level

increased circulating zinc level

Availability

Mouse Genotype

Slc39a8^em1Xijl/Slc39a8^em1Xijl

Slc39a8^tm1.1Brvo/Slc39a8^tm1.1Brvo

Slc39a8^tm1.2Mrl/Slc39a8^tm1.2Mrl

Slc39a8^{tm1b(EUCOMM)Wtsi}/Slc39a8⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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