Agpat2
Gene Detail

Symbol Name ID

Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) MGI:1914762

Synonyms

2510002J07Rik, BSCL1, LPAAT-beta

Feature Type

protein coding gene

Genetic Map

Chromosome 2

18.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:26593057-26604417 bp, - strand From VEGA annotation of GRCm38   11361 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: 1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene Tree: Agpat2

Human homologs

Human Homolog		AGPAT2, 1-acylglycerol-3-phosphate O-acyltransferase 2
NCBI Gene ID		10555
neXtProt AC		NX_O15120
Human Synonyms		1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta
Human Chr (Location)		9q34.3; chr9:139567595-139581911 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AGPAT2

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)
 

Mice homozygous for a knock-out allele exhibit loss of white and brown adipose tissue, insulin resistance, and hepatic steatosis.

 
Human Diseases Modeled Using Mouse Agpat2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	lipid metabolic process, metabolic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	1-acylglycerol-3-phosphate O-acyltransferase activity, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (118)    Tissues (95)    Images (35)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	118

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(83) cDNA(82) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011578 (Evidence)
Ensembl Gene Model	ENSMUSG00000026922 (Evidence)
Entrez Gene	67512 (Evidence)
UniGene	24244
DFCI	TC1600842, TC1600986
DoTS	DT.101358287, DT.40163370
NIA Mouse Gene Index	U022427
EC	2.3.1.51
Consensus CDS Project	CCDS15809.1
International Mouse Knockout Project Status	Agpat2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011578	VEGA Gene Model | MGI Sequence Detail	11361	C57BL/6J
transcript	OTTMUST00000027050	VEGA | MGI Sequence Detail	1489	Not Applicable
polypeptide	OTTMUSP00000012326	VEGA | MGI Sequence Detail	278	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004552	1-acyl-sn-glycerol-3-phosphate acyltransferase
InterPro	IPR002123	Phospholipid/glycerol acyltransferase
Protein Ontology	PR:000003835	1-acyl-sn-glycerol-3-phosphate acyltransferase beta

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186035 Vogel P, et al., Pathology of congenital generalized lipodystrophy in Agpat2-/- mice. Vet Pathol. 2011 May;48(3):642-54
All references(36)

Other accession IDs

MGI:2139227