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Agpat2
Gene Detail
Symbol

Name
ID
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
MGI:1914762
Synonyms
2510002J07Rik, BSCL1, LPAAT-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:26593057-26604417 bp, - strand
From VEGA annotation of GRCm38

  11361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: 1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene Tree: Agpat2

Human
homologs
Human Homolog AGPAT2, 1-acylglycerol-3-phosphate O-acyltransferase 2
NCBI Gene ID 10555
neXtProt AC  NX_O15120
Human Synonyms  1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta
Human Chr (Location)  9q34.3; chr9:136673143-136687459 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AGPAT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
 
Mice homozygous for a knock-out allele exhibit loss of white and brown adipose tissue, insulin resistance, and hepatic steatosis.
 
Human Diseases Modeled Using Mouse Agpat2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Agpat2 interacts with 49 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (118)    Tissues (95)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) cDNA(83) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011578 (Evidence)
Ensembl Gene ModelENSMUSG00000026922 (Evidence)
Entrez Gene67512 (Evidence)
UniGene24244
DFCITC1600986, TC1600842
DoTSDT.101358287, DT.40163370
NIA Mouse Gene IndexU022427
EC2.3.1.51
Consensus CDS ProjectCCDS15809.1
International Mouse Knockout Project StatusAgpat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011578 VEGA Gene Model | MGI Sequence Detail 11361 C57BL/6J ±  kb
transcript OTTMUST00000027050 VEGA | MGI Sequence Detail 1489 Not Applicable 
polypeptide OTTMUSP00000012326 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004552 1-acyl-sn-glycerol-3-phosphate acyltransferase
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000003835 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208288 Cortes VA, et al., Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors. J Lipid Res. 2014 Feb;55(2):276-88
All references(37)
Disease annotation references (1)
Other
accession IDs
MGI:2139227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory