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Slc47a1
Gene Detail
Symbol

Name
ID
Slc47a1
solute carrier family 47, member 1
MGI:1914723
Synonyms
1300013J15Rik, MATE1, mMATE1, mMATE1b
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:61343401-61378345 bp, - strand
From VEGA annotation of GRCm38

  34945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:34364  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SLC47A1
Gene Tree: Slc47a1

Human
homologs
SLC47A1, solute carrier family 47 (multidrug and toxin extrusion), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55244
neXtProt AC: NX_Q96FL8

Human Synonyms: MATE1

Human Chr (Location): 17p11.2; chr17:19533854-19579033 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Genomic Mutations involving Slc47a1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased blood urea nitrogen, increased circulating creatinine, and abnormal metformin pahrmacokinetics including increased plasma and tissue concentration with decreased kidney and liver clearance.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Slc47a1 interacts with 229 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process drug transmembrane transport, drug transport, ...
Component integral component of membrane, membrane, ...
Function antiporter activity, drug transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (218)    Tissues (185)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
RT-PCR 14
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498310 ; ZFIN slc47a1    NEW 
Molecular
reagents
All nucleic(53) cDNA(51) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005831 (Evidence)
Ensembl Gene Model ENSMUSG00000010122 (Evidence)
Entrez Gene 67473 (Evidence)
UniGene 100741
DFCI TC1580804, TC1595549
DoTS DT.40138044, DT.91340672
NIA Mouse Gene Index U032882
Consensus CDS Project CCDS24811.2
International Mouse Phenotyping Consortium Status Slc47a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005831 VEGA Gene Model | MGI Sequence Detail 34945 C57BL/6J ±  kb
transcript OTTMUST00000012942 VEGA | MGI Sequence Detail 2639 Not Applicable 
polypeptide OTTMUSP00000006022 VEGA | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002528 Multi antimicrobial extrusion protein
Protein Ontology PR:000015152 multidrug and toxin extrusion protein 1
References
(Earliest) J:66992 Douglas KR, et al., Partial transcriptome of the developing pituitary gland. Genomics. 2000 Dec 15;70(3):335-46
(Latest) J:204527 Li Q, et al., Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicol Appl Pharmacol. 2013 Nov 15;273(1):100-9
All references(44)
Other
accession IDs
MGI:2144064

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory