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Slc47a1 Gene Detail
Summary
  • Symbol
    Slc47a1
  • Name
    solute carrier family 47, member 1
  • Synonyms
    1300013J15Rik, MATE1, mMATE1, mMATE1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914723
    NCBI Gene: 67473
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61343401-61378345 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914723
protein coding gene Chr11:61343400-61378783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018437
protein coding gene Chr11:61305505-61342866 (-)
A/J MGP_AJ_G0018406
protein coding gene Chr11:59039900-59074766 (-)
AKR/J MGP_AKRJ_G0018376
protein coding gene Chr11:60883823-60918680 (-)
BALB/cJ MGP_BALBcJ_G0018377
protein coding gene Chr11:59339534-59375281 (-)
C3H/HeJ MGP_C3HHeJ_G0018190
protein coding gene Chr11:60858175-60894591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018829
protein coding gene Chr11:63247361-63284893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016475
protein coding gene Chr11:56168649-56203422 (-)
CAST/EiJ MGP_CASTEiJ_G0017747
protein coding gene Chr11:60970030-61007972 (-)
CBA/J MGP_CBAJ_G0018164
protein coding gene Chr11:65995528-66033246 (-)
DBA/2J MGP_DBA2J_G0018273
protein coding gene Chr11:58617808-58652757 (-)
FVB/NJ MGP_FVBNJ_G0018264
protein coding gene Chr11:58292625-58328054 (-)
LP/J MGP_LPJ_G0018346
protein coding gene Chr11:61872501-61913275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018288
protein coding gene Chr11:67012082-67057815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018870
protein coding gene Chr11:61013429-61049646 (-)
PWK/PhJ MGP_PWKPhJ_G0017520
protein coding gene Chr11:59214707-59250332 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017310
protein coding gene Chr11:60826819-60863130 (-)
WSB/EiJ MGP_WSBEiJ_G0017799
protein coding gene Chr11:60626180-60664288 (-)



Homology
more
  • Human Ortholog
    SLC47A1, solute carrier family 47 member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC47A1, solute carrier family 47 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MATE1
  • Links
    NCBI Gene ID: 55244
    neXtProt AC: NX_Q96FL8
    UniProt: Q96FL8

  • Chr Location
    17p11.2; chr17:19533854-19579033 (+)  GRCh38.p7

  • Human Ortholog
    SLC47A2, solute carrier family 47 member 2
    Orthology source: HGNC
  • Synonyms
    MATE2, MATE2-B, MATE2K, MATE2-K
  • Links
    NCBI Gene ID: 146802
    neXtProt AC: NX_Q86VL8
    UniProt: Q86VL8

  • Chr Location
    17p11.2; chr17:19678313-19718979 (-)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased blood urea nitrogen, increased circulating creatinine, and abnormal metformin pahrmacokinetics including increased plasma and tissue concentration with decreased kidney and liver clearance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010122 Ensembl Gene Model | MGI Sequence Detail 34945 C57BL/6J ±  kb
    transcript ENSMUST00000010267 Ensembl | MGI Sequence Detail 2639 Not Applicable  
    polypeptide ENSMUSP00000010267 Ensembl | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 52
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144064
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory