Ergic1 MGI Mouse Gene Detail - MGI:1914708 - endoplasmic reticulum-golgi intermediate compartment 1

Symbol

Ergic1
Name

endoplasmic reticulum-golgi intermediate compartment 1
Synonyms

1200007D18Rik

Feature Type

protein coding gene
IDs

MGI:1914708
NCBI Gene: 67458
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr17:26780463-26875908 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.34 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

1047 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914708	protein coding gene	Chr17:26779736-26875908 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023403	protein coding gene	Chr17:25747479-25845753 (+)
A/J	MGP_AJ_G0023362	protein coding gene	Chr17:24954863-25050653 (+)
AKR/J	MGP_AKRJ_G0023328	protein coding gene	Chr17:25083488-25180502 (+)
BALB/cJ	MGP_BALBcJ_G0023367	protein coding gene	Chr17:25209472-25305432 (+)
C3H/HeJ	MGP_C3HHeJ_G0023127	protein coding gene	Chr17:25475959-25574258 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023807	protein coding gene	Chr17:26800798-26897468 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021282	protein coding gene	Chr17:22411156-22508442 (+)
CAST/EiJ	MGP_CASTEiJ_G0022628	protein coding gene	Chr17:25406291-25505084 (+)
CBA/J	MGP_CBAJ_G0023102	protein coding gene	Chr17:27781688-27881233 (+)
DBA/2J	MGP_DBA2J_G0023232	protein coding gene	Chr17:24544023-24640220 (+)
FVB/NJ	MGP_FVBNJ_G0023202	protein coding gene	Chr17:24322371-24418405 (+)
LP/J	MGP_LPJ_G0023309	protein coding gene	Chr17:26014960-26110827 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023221	protein coding gene	Chr17:27306184-27404246 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023849	protein coding gene	Chr17:25432791-25531498 (+)
PWK/PhJ	MGP_PWKPhJ_G0022377	protein coding gene	Chr17:23338956-23436632 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022195	protein coding gene	Chr17:23496626-23606092 (+)
WSB/EiJ	MGP_WSBEiJ_G0022691	protein coding gene	Chr17:25485889-25583904 (+)

Human Ortholog

ERGIC1, endoplasmic reticulum-golgi intermediate compartment 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERGIC1, endoplasmic reticulum-golgi intermediate compartment 1
Synonyms

AMC2, AMCN, ERGIC32, ERGIC-32, NET24
Links

HGNC:29205

NCBI Gene ID: 57222

neXtProt AC: NX_Q969X5

UniProt: Q969X5
Chr Location

5q35.1; chr5:172834251-172952792 (+) GRCh38

MGI Vertebrate Homology

Ergic1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERGIC1
Gene Tree

Ergic1

Diseases

1 with human ERGIC1 associations

				Human Disease	Mouse Models
				neurogenic-type arthrogryposis multiplex congenita-2 IDs neurogenic-type arthrogryposis multiplex congenita-2 DOID:0090124 MESH:C536614 OMIM:208100 ORDO:1143 UMLS_CUI:C1859721

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

108
Endonuclease-mediated

3
Gene trapped

100
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Ergic1
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

130 strains or lines available

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All GO Annotations

14
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

121

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ergic1

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All Sequences

104
RefSeq

20
UniProt

9
CCDS

CCDS28553.1

Ensembl

ENSMUSG00000001576 (Evidence)
NCBI Gene

67458

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001576	Ensembl Gene Model \| MGI Sequence Detail	95446	C57BL/6J	± kb
transcript	ENSMUST00000167662	Ensembl \| MGI Sequence Detail	2754	Not Applicable
polypeptide	ENSMUSP00000132922	Ensembl \| MGI Sequence Detail	290	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007174 endoplasmic reticulum-Golgi intermediate compartment protein 1

(term hierarchy)
InterPro Domains

IPR045888 Endoplasmic reticulum vesicle transporter

IPR012936 Endoplasmic reticulum vesicle transporter, C-terminal

IPR039542 Endoplasmic reticulum vesicle transporter, N-terminal

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All nucleic 121

cDNA 121

Microarray probesets 6

Summaries

All 41

Gene Ontology 4

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:194116 Flachs P, et al., Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS Genet. 2012;8(11):e1003044

TSS for Ergic1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143248	Chr17:26779692-26779716 (+)	-759 bp
Tssr143249	Chr17:26780435-26780448 (+)	-21 bp
Tssr143250	Chr17:26780453-26780479 (+)	3 bp
Tssr143251	Chr17:26780489-26780566 (+)	65 bp
Tssr143252	Chr17:26790076-26790098 (+)	9,624 bp
Tssr143253	Chr17:26790140-26790147 (+)	9,681 bp
Tssr143254	Chr17:26821196-26821210 (+)	40,740 bp
Tssr143255	Chr17:26821241-26821248 (+)	40,782 bp
Tssr143256	Chr17:26826805-26826819 (+)	46,349 bp
Tssr143257	Chr17:26840486-26840495 (+)	60,028 bp
Tssr143258	Chr17:26843152-26843162 (+)	62,694 bp
Tssr143259	Chr17:26843172-26843173 (+)	62,710 bp
Tssr143260	Chr17:26874893-26874929 (+)	94,448 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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