About   Help   FAQ
Frmd8 Gene Detail
Summary
  • Symbol
    Frmd8
  • Name
    FERM domain containing 8
  • Synonyms
    1200004M23Rik, 2310035N23Rik, 4931429L16Rik, iTAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914707
    NCBI Gene: 67457
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5850974-5875273 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914707
protein coding gene Chr19:5849702-5875274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024729
protein coding gene Chr19:2855155-2880128 (-)
A/J MGP_AJ_G0024695
protein coding gene Chr19:2692274-2718381 (-)
AKR/J MGP_AKRJ_G0024668
protein coding gene Chr19:2770993-2798873 (-)
BALB/cJ MGP_BALBcJ_G0024695
protein coding gene Chr19:2685071-2710807 (-)
C3H/HeJ MGP_C3HHeJ_G0024463
protein coding gene Chr19:2783856-2809985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025142
protein coding gene Chr19:2915525-2940606 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022572
protein coding gene Chr19:2601066-2627356 (-)
CAST/EiJ MGP_CASTEiJ_G0023935
protein coding gene Chr19:2799869-2825609 (-)
CBA/J MGP_CBAJ_G0024435
protein coding gene Chr19:3052171-3083594 (-)
DBA/2J MGP_DBA2J_G0024562
protein coding gene Chr19:2686192-2710815 (-)
FVB/NJ MGP_FVBNJ_G0024528
protein coding gene Chr19:2688370-2714884 (-)
LP/J MGP_LPJ_G0024648
protein coding gene Chr19:2814807-2840702 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024558
protein coding gene Chr19:2884040-2909432 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025190
protein coding gene Chr19:2786681-2817776 (-)
PWK/PhJ MGP_PWKPhJ_G0023681
protein coding gene Chr19:2712948-2738573 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023486
protein coding gene Chr19:2776218-2804273 (-)
WSB/EiJ MGP_WSBEiJ_G0023997
protein coding gene Chr19:2795745-2825306 (-)



Homology
more
  • Human Ortholog
    FRMD8, FERM domain containing 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FRMD8, FERM domain containing 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKSG44, iTAP
  • Links
    NCBI Gene ID: 83786
    neXtProt AC: NX_Q9BZ67
    UniProt: Q9BZ67

  • Chr Location
    11q13.1; chr11:65386570-65413525 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67457 NCBI Gene Model | MGI Sequence Detail 24300 C57BL/6J ±  kb
transcript NM_026169 RefSeq | MGI Sequence Detail 3166 C57BL/6  
polypeptide Q3UFK8 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916845, MGI:1918246, MGI:2147645
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265993 Haxaire C, et al., Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-alpha pathway. Blood. 2018 Sep 6;132(10):1064-1074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory