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Sequence Detail
Q3UFK8 Q99KB3 Q9CSY6 Q8C7U3 Q9DC30 Q8C7U5 (UniProt | EBI) Last sequence update: 2007-07-24
Last annotation update: 2024-01-24
from provider
RecName: Full=FERM domain-containing protein 8;AltName: Full=iRhom tail-associated protein {ECO:0000303|PubMed:29897333}; Short=iTAP {ECO:0000303|PubMed:29897333};
Polypeptide 466 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Frmd8 FERM domain containing 8 17 98 4 13
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:264179 Oikonomidi I, et al., iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. Elife. 2018 Jun 13;7:e35032
J:264397 Kunzel U, et al., FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 2018 Jun 13;7:e35012
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory