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Daam1 Gene Detail
Summary
  • Symbol
    Daam1
  • Name
    dishevelled associated activator of morphogenesis 1
  • Synonyms
    1700066F09Rik, 2310028E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914596
    NCBI Gene: 208846
  • Gene Overview
    MyGene.info: DAAM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:71831078-71992333 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      161256 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23002
    neXtProt AC: NX_Q9Y4D1
    UniProt: Q9Y4D1

  • Chr Location
    14q23.1; chr14:59188611-59371405 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36635
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DAAM1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Daam1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele show reduced fetal size, partial embryonic and neonatal lethality, altered cytoskeletal structure, cardiac defects including ventricular noncompaction, double outlet right ventricles and ventricular septal defects, and impaired cell adhesion and wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034574 Ensembl Gene Model | MGI Sequence Detail 161256 C57BL/6J ±  kb
    transcript ENSMUST00000223272 Ensembl | MGI Sequence Detail 5835 Not Applicable  
    polypeptide ENSMUSP00000152564 Ensembl | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1682 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916850, MGI:2144851
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:253404 Nishimura T, et al., DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. J Cell Biol. 2016 Nov 21;215(4):559-573

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory