Daam1 MGI Mouse Gene Detail - MGI:1914596 - dishevelled associated activator of morphogenesis 1

Daam1 Gene Detail

Symbol

Daam1
Name

dishevelled associated activator of morphogenesis 1
Synonyms

1700066F09Rik, 2310028E21Rik

Feature Type

protein coding gene
IDs

MGI:1914596
NCBI Gene: 208846
Gene Overview

MyGene.info: DAAM1
Alliance

gene page

Sequence Map

Chr12:71831078-71992333 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

161256 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.06 cM, cytoband C3
Mapping Data

3 experiments

Human Ortholog

DAAM1, dishevelled associated activator of morphogenesis 1

Vertebrate Orthologs

10

Human Ortholog

DAAM1, dishevelled associated activator of morphogenesis 1
Orthology source: HomoloGene, HGNC
Links

HGNC:18142

NCBI Gene ID: 23002

neXtProt AC: NX_Q9Y4D1

UniProt: Q9Y4D1
Chr Location

14q23.1; chr14:59188611-59371405 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 36635
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DAAM1
Gene Tree

Daam1

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Phenotype Summary

26 phenotypes from 2 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Gene trapped

25
Targeted

4
Genomic Mutations

1 involving Daam1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available

Homozygotes for a gene trap allele show reduced fetal size, partial embryonic and neonatal lethality, altered cytoskeletal structure, cardiac defects including ventricular noncompaction, double outlet right ventricles and ventricular septal defects, and impaired cell adhesion and wound healing.

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All GO Annotations

17
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

245
Tissues

206
cDNA Data

17
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DAAM1

Xenbase daam1

ZFIN daam1a, daam1b

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Daam1 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

50
RefSeq

12
UniProt

3
CCDS

CCDS25964.1

Ensembl

ENSMUSG00000034574 (Evidence)
NCBI Gene

208846

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034574	Ensembl Gene Model \| MGI Sequence Detail	161256	C57BL/6J	± kb
transcript	ENSMUST00000223272	Ensembl \| MGI Sequence Detail	5835	Not Applicable
polypeptide	ENSMUSP00000152564	Ensembl \| MGI Sequence Detail	1077	Not Applicable

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SNPs within 2kb

1682 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000006256 disheveled-associated activator of morphogenesis 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR014767 Diaphanous autoregulatory (DAD) domain

IPR027650 Disheveled-associated activator of morphogenesis 1

IPR015425 Formin, FH2 domain

IPR010472 Formin, FH3 domain

IPR010473 Formin, GTPase-binding domain

IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain

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All nucleic 22

cDNA 17

Primer pair 5

Microarray probesets 5

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MGI:1916850, MGI:2144851

Summaries

All 62

Developmental Gene Expression 17

Gene Ontology 5

Phenotypes 18
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:253404 Nishimura T, et al., DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. J Cell Biol. 2016 Nov 21;215(4):559-573

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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