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Daam1 Gene Detail
Summary
  • Symbol
    Daam1
  • Name
    dishevelled associated activator of morphogenesis 1
  • Synonyms
    1700066F09Rik, 2310028E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914596
    NCBI Gene: 208846
  • Gene Overview
    MyGene.info: DAAM1
Location & Maps
more
  • Sequence Map
    Chr12:71831078-71992367 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      161290 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23002
    neXtProt AC: NX_Q9Y4D1

  • Chr Location
    14q23.1; chr14:59188611-59371405 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36635
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DAAM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Targeted
    3
  • Genomic Mutations
    1 involving Daam1
  • Incidental Mutations
Homozygotes for a gene trap allele show reduced fetal size, partial embryonic and neonatal lethality, altered cytoskeletal structure, cardiac defects including ventricular noncompaction, double outlet right ventricles and ventricular septal defects, and impaired cell adhesion and wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034574 Ensembl Gene Model | MGI Sequence Detail 161290 C57BL/6J ±  kb
transcript ENSMUST00000085299 Ensembl | MGI Sequence Detail 6004 Not Applicable  
polypeptide ENSMUSP00000082406 Ensembl | MGI Sequence Detail 1077 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1682 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006256 disheveled-associated activator of morphogenesis 1
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR014767 Diaphanous autoregulatory (DAD) domain
    IPR027650 Disheveled-associated activator of morphogenesis 1
    IPR015425 Formin, FH2 domain
    IPR010472 Formin, FH3 domain
    IPR010473 Formin, GTPase-binding domain
    IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Molecular
Reagents
less
  • All nucleic 22
    cDNA 17
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
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MGI:1916850, MGI:2144851
References
more
  • Summaries
    All 55
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:228507 Ajima R, et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory