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Ube2l6 Gene Detail
Summary
  • Symbol
    Ube2l6
  • Name
    ubiquitin-conjugating enzyme E2L 6
  • Synonyms
    2810489I21Rik, RIG-B, Ubce8, UBCH8, Ubcm8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914500
    NCBI Gene: 56791
  • Gene Overview
    MyGene.info: UBE2L6
Location & Maps
more
  • Sequence Map
    Chr2:84798828-84810335 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11508 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UBE2L6, ubiquitin conjugating enzyme E2 L6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    UBE2L6, ubiquitin conjugating enzyme E2 L6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIG-B, UBCH8
  • Links
    NCBI Gene ID: 9246
    neXtProt AC: NX_O14933

  • Chr Location
    11q12; chr11:57551655-57568330 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    4
  • Genomic Mutations
    3 involving Ube2l6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013725 VEGA Gene Model | MGI Sequence Detail 11508 C57BL/6J ±  kb
transcript OTTMUST00000032887 VEGA | MGI Sequence Detail 1560 Not Applicable  
polypeptide OTTMUSP00000014694 VEGA | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016981 ubiquitin/ISG15-conjugating enzyme E2 L6
  • EC
  • InterPro Domains
    IPR023313 Ubiquitin-conjugating enzyme, active site
    IPR000608 Ubiquitin-conjugating enzyme E2
    IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Molecular
Reagents
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  • All nucleic 84
    cDNA 84

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:223708 Wood LM, et al., A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. PLoS One. 2011;6(1):e16422

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory