Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ISG15 transferase activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in liver. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6).