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Mtdh Gene Detail
Summary
  • Symbol
    Mtdh
  • Name
    metadherin
  • Synonyms
    2610103J23Rik, 3D3/Lyric, AEG-1, D8Bwg1112e, Lyric
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914404
    NCBI Gene: 67154
  • Gene Overview
    MyGene.info: MTDH
Location & Maps
more
  • Sequence Map
    Chr15:34082694-34142386 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 13.98 cM, cytoband B3.3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MTDH, metadherin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MTDH, metadherin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3
  • Links
    NCBI Gene ID: 92140
    neXtProt AC: NX_Q86UE4

  • Chr Location
    8q22.1; chr8:97644147-97730260 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12089
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: MTDH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    18
  • Targeted
    3
  • Genomic Mutations
    2 involving Mtdh
  • Incidental Mutations
Mice homozygous for a null allele are viable and fertile with decreased incidence of tumors by chemical induction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036553 VEGA Gene Model | MGI Sequence Detail 59693 C57BL/6J ±  kb
transcript OTTMUST00000093737 VEGA | MGI Sequence Detail 3681 Not Applicable  
polypeptide OTTMUSP00000052069 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    300 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 174
    Genomic 1
    cDNA 171
    Primer pair 2

    Microarray probesets 11
Other
Accession IDs
less
MGD-MRK-34124, MGI:106430, MGI:2146175
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:223321 Srivastava J, et al., Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC). J Biol Chem. 2015 Jun 19;290(25):15549-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory