Rnaseh2b
Gene Detail

Symbol Name ID

Rnaseh2b ribonuclease H2, subunit B MGI:1914403

Synonyms

1110019N06Rik, 2610207P08Rik, Dleu8

Feature Type

protein coding gene

Genetic Map

Chromosome 14

33.19 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:62292589-62372992 bp, + strand From VEGA annotation of GRCm38   80404 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rnaseh2b ± 2 cM)

Gene Tree: Rnaseh2b

Human ortholog

RNASEH2B ribonuclease H2, subunit B NCBI Gene ID 79621
Human Synonyms: AGS2, DLEU8
Human Chr13:51483892-51544596 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human RNASEH2B (1)

Alleles and phenotypes

All alleles(65) : Targeted(4) Gene trapped(61)
 

Mice homozygous for a knock-out allele exhibit preweaning lethality associated with reduced cell proliferation and embryonic growth retardation.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	RNA catabolic process
Component	nucleus, ribonuclease H2 complex
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (72)    Tissues (6)    Images (20)
Theiler Stages: 23

Assay Type	Results
RNA in situ	72

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(41)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000019771 (Evidence)
Ensembl Gene Model	ENSMUSG00000021932 (Evidence)
Entrez Gene	67153 (Evidence)
UniGene	26040
DFCI	TC1580019
DoTS	DT.101246341, DT.101348322
NIA Mouse Gene Index	U015733
PDB	3KIO, 3P5J
Consensus CDS Project	CCDS27189.1
International Mouse Knockout Project Status	Rnaseh2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019771	VEGA Gene Model | MGI Sequence Detail	80404	C57BL/6J
transcript	OTTMUST00000047290	VEGA | MGI Sequence Detail	1494	Not Applicable
polypeptide	OTTMUSP00000021344	VEGA | MGI Sequence Detail	308	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(275 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019024	Ribonuclease H2, subunit B
Protein Ontology	PR:000014055	ribonuclease H2 subunit B

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186986 Hiller B, et al., Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. J Exp Med. 2012 Jul 30;209(8):1419-26
All references(40)

Other accession IDs

MGI:1915767