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Rnaseh2b Gene Detail
Summary
  • Symbol
    Rnaseh2b
  • Name
    ribonuclease H2, subunit B
  • Synonyms
    1110019N06Rik, 2610207P08Rik, Dleu8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914403
    NCBI Gene: 67153
Location & Maps
more
  • Sequence Map
    Chr14:62292589-62372992 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80404 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.19 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNASEH2B, ribonuclease H2 subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNASEH2B, ribonuclease H2 subunit B
    Orthology source: HomoloGene
  • Synonyms
    AGS2, DLEU8
  • Links
    NCBI Gene ID: 79621
    neXtProt AC: NX_Q5TBB1

  • Chr Location
    13q14.3; chr13:50909678-50970462 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RNASEH2B associations

Human Disease Mouse Models
       Aicardi-Goutieres Syndrome 2; AGS2   OMIM: 610181
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Chemically induced (other)
    1
  • Gene trapped
    61
  • Targeted
    5
  • Genomic Mutations
    2 involving Rnaseh2b
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit preweaning lethality associated with reduced cell proliferation and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019771 VEGA Gene Model | MGI Sequence Detail 80404 C57BL/6J ±  kb
transcript OTTMUST00000047290 VEGA | MGI Sequence Detail 1494 Not Applicable  
polypeptide OTTMUSP00000021344 VEGA | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    675 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 41
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915767
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory