About   Help   FAQ
Rnaseh2b
Gene Detail
 Symbol
Name
ID
Rnaseh2b
ribonuclease H2, subunit B
MGI:1914403
Synonyms 1110019N06Rik, 2610207P08Rik, Dleu8
Feature Type protein coding gene
Genetic Map
Chromosome 14
33.19 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:62292589-62372992 bp, + strand
From VEGA annotation of GRCm38

  80404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rnaseh2b

Human
homologs
Human Homolog RNASEH2B, ribonuclease H2, subunit B
NCBI Gene ID 79621
neXtProt AC  NX_Q5TBB1
Human Synonyms  AGS2, DLEU8
Human Chr (Location)  13q14.3; chr13:50909678-50970460 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RNASEH2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(66) : Gene trapped(61) Targeted(5)
Genomic Mutations involving Rnaseh2b (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit preweaning lethality associated with reduced cell proliferation and embryonic growth retardation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Rnaseh2b interacts with 79 markers (Mir27b, Mir31, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process in utero embryonic development, negative regulation of gene expression, ...
Component nucleus, ribonuclease H2 complex
Function RNA-DNA hybrid ribonuclease activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (72)    Tissues (6)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 72
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019771 (Evidence)
Ensembl Gene ModelENSMUSG00000021932 (Evidence)
Entrez Gene67153 (Evidence)
UniGene26040
DFCITC1580019
DoTSDT.101246341, DT.101348322
NIA Mouse Gene IndexU015733
PDB3KIO, 3P5J
Consensus CDS ProjectCCDS27189.1
International Mouse Knockout Project StatusRnaseh2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019771 VEGA Gene Model | MGI Sequence Detail 80404 C57BL/6J ±  kb
transcript OTTMUST00000047290 VEGA | MGI Sequence Detail 1494 Not Applicable 
polypeptide OTTMUSP00000021344 VEGA | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(461 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019024 Ribonuclease H2, subunit B
Protein Ontology PR:000014055 ribonuclease H2 subunit B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32
All references(38)
Other
accession IDs
MGI:1915767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory