Gatm
Gene Detail

Symbol Name ID

Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) MGI:1914342

Synonyms

1810003P21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:122594467-122611303 bp, - strand From VEGA annotation of GRCm38   16837 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: scyllo-inosamine-4-phosphate amidinotransferase
Gene Tree: Gatm

Human homologs

Human Homolog		GATM, glycine amidinotransferase (L-arginine:glycine amidinotransferase)
NCBI Gene ID		2628
neXtProt AC		NX_P50440
Human Synonyms		AGAT, AT
Human Chr (Location)		15q21.1; chr15:45653322-45670980 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GATM

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit resistance obesity, reduced adipocity and improved glucose homeostasis when fed a high fat diet.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	creatine biosynthetic process, response to mercury ion, ...
Component	cytoplasm, membrane, ...
Function	amidinotransferase activity, glycine amidinotransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (259)    Tissues (148)    Images (33)
Theiler Stages: 6, 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	209
Northern blot	32
RT-PCR	18

cDNA source data(158)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(159) cDNA(158) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015672 (Evidence)
Ensembl Gene Model	ENSMUSG00000027199 (Evidence)
Entrez Gene	67092 (Evidence)
UniGene	29975
DFCI	TC1572172
DoTS	DT.495473
NIA Mouse Gene Index	U023279
EC	2.1.4.1
Consensus CDS Project	CCDS16665.1
International Mouse Knockout Project Status	Gatm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015672	VEGA Gene Model | MGI Sequence Detail	16837	C57BL/6J
transcript	OTTMUST00000037236	VEGA | MGI Sequence Detail	2389	Not Applicable
polypeptide	OTTMUSP00000016683	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(109 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003198	Amidinotransferase
Protein Ontology	PR:000007865	glycine amidinotransferase, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191142 Choe CU, et al., L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome. Hum Mol Genet. 2013 Jan 1;22(1):110-23
All references(40)

Other accession IDs

MGI:2138882