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Gatm
Gene Detail
 Symbol
Name
ID
Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
MGI:1914342
Synonyms 1810003P21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:122594467-122611303 bp, - strand
From VEGA annotation of GRCm38

  16837 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: scyllo-inosamine-4-phosphate amidinotransferase
Gene Tree: Gatm

Human
homologs
Human Homolog GATM, glycine amidinotransferase (L-arginine:glycine amidinotransferase)
NCBI Gene ID 2628
neXtProt AC  NX_P50440
Human Synonyms  AGAT, AT, CCDS3
Human Chr (Location)  15q21.1; chr15:45361124-45378782 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GATM
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit resistance obesity, reduced adipocity and improved glucose homeostasis when fed a high fat diet.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process creatine biosynthetic process, response to mercury ion, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function amidinotransferase activity, glycine amidinotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (259)    Tissues (148)    Images (33)
Theiler Stages: 6, 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 209
Northern blot 32
RT-PCR 18
cDNA source data(168)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(169) cDNA(168) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015672 (Evidence)
Ensembl Gene ModelENSMUSG00000027199 (Evidence)
Entrez Gene67092 (Evidence)
UniGene29975
DFCITC1572172
DoTSDT.495473
NIA Mouse Gene IndexU023279
EC2.1.4.1
Consensus CDS ProjectCCDS16665.1
International Mouse Knockout Project StatusGatm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015672 VEGA Gene Model | MGI Sequence Detail 16837 C57BL/6J ±  kb
transcript OTTMUST00000037236 VEGA | MGI Sequence Detail 2389 Not Applicable 
polypeptide OTTMUSP00000016683 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003198 Amidinotransferase
Protein Ontology PR:000007865 glycine amidinotransferase, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201173 Stockebrand M, et al., Differential regulation of AMPK activation in leptin- and creatine-deficient mice. FASEB J. 2013 Oct;27(10):4147-4156
All references(44)
Other
accession IDs
MGI:2138882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory