Symbol
Name
ID

Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
MGI:1914342

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Hypokalemia	Hypophosphatemia	Elevated circulating alkaline phosphatase concentration	Reduced tissue arginine:glycine amidinotransferase activity	Metabolic acidosis	Hyperphosphaturia	Glycosuria	Low-molecular-weight proteinuria	Aminoaciduria	Lacticaciduria	Organic aciduria
Disease(s) Associated with GATM	Hypokalemia	Hypophosphatemia	Elevated circulating alkaline phosphatase concentration	Reduced tissue arginine:glycine amidinotransferase activity	Metabolic acidosis	Hyperphosphaturia	Glycosuria	Low-molecular-weight proteinuria	Aminoaciduria	Lacticaciduria	Organic aciduria
AGAT deficiency
Fanconi renotubular syndrome 1

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased susceptibility to diet-induced obesity

decreased urine creatine level

decreased creatine level

abnormal urine amino acid level

decreased urine creatinine level

decreased circulating glucose level

decreased circulating insulin level

decreased circulating leptin level

decreased circulating cholesterol level

decreased circulating triglyceride level

increased circulating potassium level

decreased circulating alkaline phosphatase level

increased circulating amylase level

increased circulating aspartate transaminase level

decreased respiratory quotient

abnormal glucose homeostasis

abnormal gluconeogenesis

improved glucose tolerance

decreased liver triglyceride level

increased susceptibility to xenobiotic induced morbidity/mortality

increased physiological sensitivity to xenobiotic

Availability

Mouse Genotype

Gatm^em1Btlr/Gatm^em1Btlr

Gatm^m1Btlr/Gatm^m1Btlr

Gatm^tm1.1Isb/Gatm^tm1.1Isb

Gatm^{tm1b(KOMP)Wtsi}/Gatm^{tm1b(KOMP)Wtsi}

Gatm^m1Btlr/Gatm⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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