Paics MGI Mouse Gene Detail - MGI:1914304 - phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

Symbol

Paics
Name

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
Synonyms

2610511I09Rik, ADE2H1, AIRC, PAIS

Feature Type

protein coding gene
IDs

MGI:1914304
NCBI Gene: 67054
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:76951307-76967509 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.45 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

95 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914304	protein coding gene	Chr5:76951302-76967509 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029650	protein coding gene	Chr5:77165024-77181453 (+)
A/J	MGP_AJ_G0029618	protein coding gene	Chr5:74214751-74230958 (+)
AKR/J	MGP_AKRJ_G0029566	protein coding gene	Chr5:76636262-76653770 (+)
BALB/cJ	MGP_BALBcJ_G0029627	protein coding gene	Chr5:74948873-74965650 (+)
C3H/HeJ	MGP_C3HHeJ_G0029350	protein coding gene	Chr5:77010167-77026301 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030081	protein coding gene	Chr5:80248333-80265321 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027322	protein coding gene	Chr5:69845979-69861896 (+)
CAST/EiJ	MGP_CASTEiJ_G0028758	protein coding gene	Chr5:76210459-76230698 (+)
CBA/J	MGP_CBAJ_G0029319	protein coding gene	Chr5:82889514-82908046 (+)
DBA/2J	MGP_DBA2J_G0029464	protein coding gene	Chr5:74271992-74291839 (+)
FVB/NJ	MGP_FVBNJ_G0029425	protein coding gene	Chr5:73472872-73489492 (+)
LP/J	MGP_LPJ_G0029551	protein coding gene	Chr5:77602394-77618587 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029453	protein coding gene	Chr5:86029938-86048132 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030114	protein coding gene	Chr5:76182286-76199146 (+)
PWK/PhJ	MGP_PWKPhJ_G0028481	protein coding gene	Chr5:73290943-73307502 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028316	protein coding gene	Chr5:75539574-75556424 (+)
WSB/EiJ	MGP_WSBEiJ_G0028838	protein coding gene	Chr5:76513251-76530832 (+)

Human Ortholog

PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

Vertebrate Orthologs

9

Human Ortholog

PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Orthology source: HomoloGene, HGNC
Synonyms

ADE2, ADE2H1, AIRC, PAIS
Links

HGNC:8587

NCBI Gene ID: 10606

neXtProt AC: NX_P22234

UniProt: P22234
Chr Location

4q12; chr4:56435749-56461368 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4710
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PAICS
Gene Tree

Paics

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

70
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

66
Spontaneous

1
Genomic Mutations

3 involving Paics
Incidental Mutations

APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

136
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase paics.1, paics.2

ZFIN paics

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Paics interacts with 110 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

61
RefSeq

12
UniProt

3
CCDS

CCDS19367.1

Ensembl

ENSMUSG00000029247 (Evidence)
NCBI Gene

67054

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029247	Ensembl Gene Model \| MGI Sequence Detail	16203	C57BL/6J	± kb
transcript	ENSMUST00000031160	Ensembl \| MGI Sequence Detail	2482	Not Applicable
polypeptide	ENSMUSP00000031160	Ensembl \| MGI Sequence Detail	425	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012235 multifunctional protein ADE2

(term hierarchy)
EC

4.1.1.21, 6.3.2.6
InterPro Domains

IPR033626 Class II PurE

IPR000031 PurE domain

IPR035893 PurE domain superfamily

IPR028923 SAICAR synthetase/ADE2, N-terminal

IPR018236 SAICAR synthetase, conserved site

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:237661 Lastwika KJ, et al., Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res. 2016 Jan 15;76(2):227-38

TSS for Paics:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46751	Chr5:76951325-76951363 (+)	37 bp
Tssr46752	Chr5:76951383-76951394 (+)	82 bp
Tssr46753	Chr5:76951627-76951638 (+)	326 bp
Tssr46754	Chr5:76951716-76951795 (+)	449 bp
Tssr46755	Chr5:76951799-76951811 (+)	498 bp
Tssr46756	Chr5:76965939-76965942 (+)	14,634 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16