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Paics Gene Detail
Summary
  • Symbol
    Paics
  • Name
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  • Synonyms
    2610511I09Rik, ADE2H1, AIRC, PAIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914304
    NCBI Gene: 67054
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:76951307-76967509 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16203 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.45 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADE2, ADE2H1, AIRC, PAIS
  • Links
    NCBI Gene ID: 10606
    neXtProt AC: NX_P22234
    UniProt: P22234

  • Chr Location
    4q12; chr4:56435749-56461368 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    70
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    66
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Paics
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    39 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    218
  • Tissues
    136
  • cDNA Data
    12
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026550 VEGA Gene Model | MGI Sequence Detail 16203 C57BL/6J ±  kb
transcript OTTMUST00000065693 VEGA | MGI Sequence Detail 2482 Not Applicable  
polypeptide OTTMUSP00000032772 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237661 Lastwika KJ, et al., Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res. 2016 Jan 15;76(2):227-38
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/15/2018
MGI 6.12 		The Jackson Laboratory