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Ddx17 Gene Detail
Summary
  • Symbol
    Ddx17
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
  • Synonyms
    2610007K22Rik, A430025E01Rik, LOC381024, p72
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914290
    NCBI Gene: 67040
  • Gene Overview
    MyGene.info: DDX17
Location & Maps
more
  • Sequence Map
    Chr15:79527707-79546741 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19035 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.77 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DDX17, DEAD-box helicase 17
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX17, DEAD-box helicase 17
    Orthology source: HomoloGene
  • Synonyms
    P72, RH70
  • Links
    NCBI Gene ID: 10521
    neXtProt AC: NX_Q92841

  • Chr Location
    22q13.1; chr22:38483438-38506340 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Chemically induced (other)
    1
  • Gene trapped
    59
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Ddx17
  • Incidental Mutations
Mice homozygous for a null allele exhibit defects in vascular development, reduced body size and death on the second day of life. Cultured embryonic fibroblasts display a severe reduction in growth rate and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055065 Ensembl Gene Model | MGI Sequence Detail 19035 C57BL/6J ±  kb
transcript ENSMUST00000054014 Ensembl | MGI Sequence Detail 4761 Not Applicable  
polypeptide ENSMUSP00000055535 Ensembl | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 642
    cDNA 641
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2145942, MGI:2146298, MGI:2685772
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:223034 Krol J, et al., A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015;6:7305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory