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Ddx17
Gene Detail
 Symbol
Name
ID
Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
MGI:1914290
Synonyms 2610007K22Rik, A430025E01Rik, LOC381024, p72
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:79527707-79546741 bp, - strand
From Ensembl annotation of GRCm38

  19035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101101  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ATP-dependent RNA helicase
Gene Tree: Ddx17

Human
homologs
Human Homolog DDX17, DEAD (Asp-Glu-Ala-Asp) box helicase 17
NCBI Gene ID 10521
neXtProt AC  NX_Q92841
Human Synonyms  P72, RH70
Human Chr (Location)  22q13.1; chr22:38483438-38506340 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(59) Radiation induced(1) Targeted(3)
Genomic Mutations involving Ddx17 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit defects in vascular development, reduced body size and death on the second day of life. Cultured embryonic fibroblasts display a severe reduction in growth rate and increased apoptosis.
 
Interactions
Ddx17 interacts with 319 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cardiovascular system development, positive regulation of intracellular estrogen receptor signaling pathway, ...
Component membrane, nucleus
Function ATP binding, ATP-dependent helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (241)    Tissues (47)    Images (37)
Theiler Stages: 15, 19, 23, 28
Assay TypeResults
RNA in situ 234
In situ reporter (knock in) 1
Western blot 6
cDNA source data(640)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(642) cDNA(641) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000055065 (Evidence)
Entrez Gene67040 (Evidence)
UniGene29644
DFCITC1573926, TC1585924, TC1588277, TC1640325, TC1749544
NIA Mouse Gene IndexU036407
EC3.6.4.13
Consensus CDS ProjectCCDS27643.1
International Mouse Knockout Project StatusDdx17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055065 Ensembl Gene Model | MGI Sequence Detail 19035 C57BL/6J ±  kb
transcript ENSMUST00000054014 Ensembl | MGI Sequence Detail 4761 Not Applicable 
polypeptide ENSMUSP00000055535 Ensembl | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(15) UniProt(6)
Polymorphisms SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000029383 ATP-dependent RNA helicase DDX17
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211315 Mori M, et al., Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27;156(5):893-906
All references(39)
Other
accession IDs
MGI:2145942, MGI:2146298, MGI:2685772

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory