About   Help   FAQ
Fancl
Gene Detail
Symbol

Name
ID
Fancl
Fanconi anemia, complementation group L
MGI:1914280
Synonyms
2010322C19Rik, B230118H11Rik, gcd, Phf9, Pog
Feature Type
protein coding gene
Genetic Map
Chromosome 11
15.85 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:26386135-26471876 bp, + strand
From VEGA annotation of GRCm38

  85742 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fancl

Human
homologs
Human Homolog FANCL, Fanconi anemia, complementation group L
NCBI Gene ID 55120
neXtProt AC  NX_Q9NW38
Human Synonyms  FAAP43, PHF9, POG
Human Chr (Location)  2p16.1; chr2:58159243-58241381 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FANCL
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygosity for mutations that inactivate the allele results in male and female infertility due to a defects in primordial germ cell proliferation. Homozygosity is embryonic lethal on some backgrounds.
 
Human Diseases Modeled Using Mouse Fancl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Fancl interacts with 79 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (71)    Tissues (16)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 45
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008088 (Evidence)
Ensembl Gene ModelENSMUSG00000004018 (Evidence)
Entrez Gene67030 (Evidence)
NIA Mouse Gene IndexU012397
EC6.3.2.-
Consensus CDS ProjectCCDS24485.1, CCDS70152.1
International Mouse Knockout Project StatusFancl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008088 VEGA Gene Model | MGI Sequence Detail 85742 C57BL/6J ±  kb
transcript OTTMUST00000018377 VEGA | MGI Sequence Detail 2724 Not Applicable 
polypeptide OTTMUSP00000008445 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(839 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026848 E3 ubiquitin-protein ligase FANCL
InterPro IPR019162 Fanconi anemia complex, subunit FancL, WD-repeat containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000007338 E3 ubiquitin-protein ligase FANCL
References
(Earliest) J:21254 Pellas TC, et al., Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8787-91
(Latest) J:199404 Jamsai D, et al., Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS One. 2013;8(2):e56955
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10019, MGI:1926122, MGI:2144571, MGI:95673

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory