Sdha
Gene Detail

Symbol Name ID

Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) MGI:1914195

Synonyms

2310034D06Rik, FP, SDH2, SDHF

Feature Type

protein coding gene

Genetic Map

Chromosome 13

40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:74322254-74350280 bp, - strand From VEGA annotation of GRCm38   28027 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sdha

Human homologs

Human Homolog		SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
NCBI Gene ID		6389
neXtProt AC		NX_P31040
Human Synonyms		CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
Human Chr (Location)		5p15; chr5:218356-256815 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human SDHA

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	electron transport chain, nervous system development, ...
Component	membrane, mitochondrial inner membrane, ...
Function	flavin adenine dinucleotide binding, oxidoreductase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (118)    Tissues (97)    Images (17)
Theiler Stages: 22

Assay Type	Results
RNA in situ	118

cDNA source data(426)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(428) cDNA(427) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030724 (Evidence)
Ensembl Gene Model	ENSMUSG00000021577 (Evidence)
Entrez Gene	66945 (Evidence)
UniGene	158231
DFCI	TC1573860, TC1592932, TC1682889
DoTS	DT.101393429, DT.101393435, DT.110973944, DT.111201324, DT.537110, DT.55133555, DT.91568843, DT.94400276
NIA Mouse Gene Index	U034969
EC	1.3.5.1
Consensus CDS Project	CCDS26643.1
International Mouse Knockout Project Status	Sdha

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030724	VEGA Gene Model | MGI Sequence Detail	28027	C57BL/6J
transcript	OTTMUST00000076054	VEGA | MGI Sequence Detail	2900	Not Applicable
polypeptide	OTTMUSP00000039973	VEGA | MGI Sequence Detail	664	Not Applicable

All sequences(86) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(186 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003953	FAD binding domain
InterPro	IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site
InterPro	IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
InterPro	IPR011281	Succinate dehydrogenase, flavoprotein subunit
InterPro	IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Protein Ontology	PR:000014563	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184825 Xiao M, et al., Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012 Jun 15;26(12):1326-38
All references(52)

Other accession IDs

MGI:2145519