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Sdha Gene Detail
Summary
  • Symbol
    Sdha
  • Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
  • Synonyms
    2310034D06Rik, FP, SDH2, SDHF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914195
    NCBI Gene: 66945
  • Gene Overview
    MyGene.info: SDHA
Location & Maps
more
  • Sequence Map
    Chr13:74322254-74350280 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28027 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
  • Links
    NCBI Gene ID: 6389
    neXtProt AC: NX_P31040

  • Chr Location
    5p15; chr5:218223-264816 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3073
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SDHA
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with human SDHA associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1gg; CMD1GG   OMIM: 613642
Leigh Syndrome; LS   OMIM: 256000
Mitochondrial Complex II Deficiency   OMIM: 252011
Paragangliomas 5; PGL5   OMIM: 614165
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    4
  • Genomic Mutations
    1 involving Sdha
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030724 VEGA Gene Model | MGI Sequence Detail 28027 C57BL/6J ±  kb
transcript OTTMUST00000076054 VEGA | MGI Sequence Detail 2900 Not Applicable  
polypeptide OTTMUSP00000039973 VEGA | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    271 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014563 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
  • EC
  • InterPro Domains
    IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
    IPR023753 FAD/NAD(P)-binding domain
    IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
    IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
    IPR011281 Succinate dehydrogenase, flavoprotein subunit
    IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit
    IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
    IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Molecular
Reagents
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  • All nucleic 425
    cDNA 424
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145519
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:224980 Lee KY, et al., Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory