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Sdha Gene Detail
Summary
  • Symbol
    Sdha
  • Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
  • Synonyms
    2310034D06Rik, FP, SDH2, SDHF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914195
    NCBI Gene: 66945
  • Gene Overview
    MyGene.info: SDHA
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74322255-74350240 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914195
protein coding gene Chr13:74322254-74350280 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020763
protein coding gene Chr13:74822769-74851111 (-)
A/J MGP_AJ_G0020719
protein coding gene Chr13:72150655-72178790 (-)
AKR/J MGP_AKRJ_G0020693
protein coding gene Chr13:74407741-74435815 (-)
BALB/cJ MGP_BALBcJ_G0020716
protein coding gene Chr13:72643707-72672249 (-)
C3H/HeJ MGP_C3HHeJ_G0020510
protein coding gene Chr13:74096875-74123673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021153
protein coding gene Chr13:77303325-77333605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018720
protein coding gene Chr13:68980660-69008915 (-)
CAST/EiJ MGP_CASTEiJ_G0020027
protein coding gene Chr13:73180773-73208454 (-)
CBA/J MGP_CBAJ_G0020469
protein coding gene Chr13:80177326-80207569 (-)
DBA/2J MGP_DBA2J_G0020594
protein coding gene Chr13:71969174-71997206 (-)
FVB/NJ MGP_FVBNJ_G0020574
protein coding gene Chr13:70993851-71020423 (-)
LP/J MGP_LPJ_G0020667
protein coding gene Chr13:75057836-75086733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020602
protein coding gene Chr13:78582100-78610504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021192
protein coding gene Chr13:73728501-73756494 (-)
PWK/PhJ MGP_PWKPhJ_G0019781
protein coding gene Chr13:70711634-70739561 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019604
protein coding gene Chr13:70218623-70248002 (-)
WSB/EiJ MGP_WSBEiJ_G0020085
protein coding gene Chr13:74284045-74312352 (-)



Homology
more
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
  • Links
    NCBI Gene ID: 6389
    neXtProt AC: NX_P31040
    UniProt: P31040

  • Chr Location
    5p15.33; chr5:218223-264816 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3073
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SDHA
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with human SDHA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66945 NCBI Gene Model | MGI Sequence Detail 27986 C57BL/6J ±  kb
    transcript NM_023281 RefSeq | MGI Sequence Detail 2859 C57BL/6  
    polypeptide Q8K2B3 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014563 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    • EC
    • InterPro Domains
      IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
      IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
      IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
      IPR011281 Succinate dehydrogenase, flavoprotein subunit
      IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
      IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    Molecular
    Reagents
    less
    • All nucleic 425
      cDNA 424
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145519
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 17
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257856 Hilander T, et al., Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Nucleic Acids Res. 2018 Jan 25;46(2):849-860

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory