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Sdha
Gene Detail
Symbol

Name
ID
Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
MGI:1914195
Synonyms
2310034D06Rik, FP, SDH2, SDHF
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:74322254-74350280 bp, - strand
From VEGA annotation of GRCm38

  28027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sdha

Human
homologs
Human Homolog SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
NCBI Gene ID 6389
neXtProt AC  NX_P31040
Human Synonyms  CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
Human Chr (Location)  5p15; chr5:218223-256700 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human SDHA
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sdha interacts with 132 markers (Mir16-2, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process electron transport chain, nervous system development, ...
Component membrane, mitochondrial inner membrane, ...
Function flavin adenine dinucleotide binding, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (118)    Tissues (97)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
cDNA source data(423)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(425) cDNA(424) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030724 (Evidence)
Ensembl Gene ModelENSMUSG00000021577 (Evidence)
Entrez Gene66945 (Evidence)
UniGene158231
DFCITC1573860, TC1592932, TC1682889
DoTSDT.101393435, DT.101393429, DT.537110, DT.111201324, DT.110973944, DT.94400276, DT.55133555, DT.91568843
NIA Mouse Gene IndexU034969
EC1.3.5.1
Consensus CDS ProjectCCDS26643.1
International Mouse Knockout Project StatusSdha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030724 VEGA Gene Model | MGI Sequence Detail 28027 C57BL/6J ±  kb
transcript OTTMUST00000076054 VEGA | MGI Sequence Detail 2900 Not Applicable 
polypeptide OTTMUSP00000039973 VEGA | MGI Sequence Detail 664 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003953 FAD binding domain
InterPro IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
InterPro IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
InterPro IPR011281 Succinate dehydrogenase, flavoprotein subunit
InterPro IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
InterPro IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Protein Ontology PR:000014563 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184825 Xiao M, et al., Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012 Jun 15;26(12):1326-38
All references(54)
Other
accession IDs
MGI:2145519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory