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Sdha Gene Detail
Summary
  • Symbol
    Sdha
  • Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
  • Synonyms
    2310034D06Rik, FP, SDH2, SDHF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914195
    NCBI Gene: 66945
  • Gene Overview
    MyGene.info: SDHA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:74322254-74350280 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28027 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHA, succinate dehydrogenase complex flavoprotein subunit A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
  • Links
    NCBI Gene ID: 6389
    neXtProt AC: NX_P31040
    UniProt: P31040

  • Chr Location
    5p15.33; chr5:218223-264816 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3073
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SDHA
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with human SDHA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030724 VEGA Gene Model | MGI Sequence Detail 28027 C57BL/6J ±  kb
    transcript OTTMUST00000076054 VEGA | MGI Sequence Detail 2900 Not Applicable  
    polypeptide OTTMUSP00000039973 VEGA | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      271 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014563 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    • EC
    • InterPro Domains
      IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
      IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
      IPR037099 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
      IPR011281 Succinate dehydrogenase, flavoprotein subunit
      IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
      IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    Molecular
    Reagents
    less
    • All nucleic 425
      cDNA 424
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145519
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257856 Hilander T, et al., Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Nucleic Acids Res. 2018 Jan 25;46(2):849-860

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory