Sdhd
Gene Detail

Symbol Name ID

Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein MGI:1914175

Synonyms

3110001M13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

27.75 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:50596340-50603849 bp, - strand From NCBI annotation of GRCm38   7510 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mitochondrial succinate dehydrogenase [ubiquinone] cytochrome b, small subunit, animal type
Gene Tree: Sdhd

Human homologs

Human Homolog		SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein
NCBI Gene ID		6392
neXtProt AC		NX_O14521
Human Synonyms		CBT1, CII-4, CWS3, cybS, PGL, PGL1, QPs3, SDH4
Human Chr (Location)		11q23; chr11:111957571-111966518 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human SDHD

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)
 

Homozygous null mice die before E7.5. Heterozygotes show a deficiency in succinate dehydrogenase activity and an abnormal enhancement of resting carotid body activity due to a decrease of potassium conductance and persistent calcium influx into glomus cells.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	electron transport chain, transport, ...
Component	integral to membrane, membrane, ...
Function	metal ion binding, succinate dehydrogenase activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (131)    Tissues (109)    Images (25)
Theiler Stages: 17, 21, 22, 28

Assay Type	Results
RNA in situ	123
RT-PCR	8

cDNA source data(271)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(274) cDNA(271) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000000171 (Evidence)
Entrez Gene	66925 (Evidence)
UniGene	10406
DFCI	TC1571895, TC1744535, TC1751690
DoTS	DT.101382544, DT.536915, DT.94356812, DT.94356850
NIA Mouse Gene Index	U030842
Consensus CDS Project	CCDS40623.1
International Mouse Knockout Project Status	Sdhd

Sequences

Length	Strain/Species
genomic	66925	NCBI Gene Model | MGI Sequence Detail	7510	C57BL/6J
transcript	NM_025848	RefSeq | MGI Sequence Detail	1287	C57BL/6
polypeptide	Q9CXV1	UniProt | EBI | MGI Sequence Detail	159	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007992	Cytochrome b, succinate dehydrogenase small subunit, CybS
Protein Ontology	PR:000014566	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:186713 Diaz-Castro B, et al., Differential Impairment of Catecholaminergic Cell Maturation and Survival by Genetic Mitochondrial Complex II Dysfunction. Mol Cell Biol. 2012 Aug;32(16):3347-57
All references(46)

Other accession IDs

MGI:2143396