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Sdhd
Gene Detail
Symbol

Name
ID
Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
MGI:1914175
Synonyms
3110001M13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
27.75 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:50596340-50603849 bp, - strand
From NCBI annotation of GRCm38

  7510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mitochondrial succinate dehydrogenase [ubiquinone] cytochrome b, small subunit, animal type
Gene Tree: Sdhd

Human
homologs
Human Homolog SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein
NCBI Gene ID 6392
neXtProt AC  NX_O14521
Human Synonyms  CBT1, CII-4, CWS3, cybS, PGL, PGL1, QPs3, SDH4
Human Chr (Location)  11q23; chr11:112086824-112095801 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human SDHD
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(20) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die before E7.5. Heterozygotes show a deficiency in succinate dehydrogenase activity and an abnormal enhancement of resting carotid body activity due to a decrease of potassium conductance and persistent calcium influx into glomus cells.
 
Interactions
Sdhd interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to hypoxia, oxidation-reduction process, ...
Component integral component of membrane, membrane, ...
Function metal ion binding, succinate dehydrogenase activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (156)    Tissues (134)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 148
RT-PCR 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000171 (Evidence)
Entrez Gene66925 (Evidence)
DFCITC1744535, TC1751690, TC1571895
DoTSDT.101382544, DT.94356812, DT.536915, DT.94356850
NIA Mouse Gene IndexU030842
Consensus CDS ProjectCCDS40623.1
International Mouse Knockout Project StatusSdhd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66925 NCBI Gene Model | MGI Sequence Detail 7510 C57BL/6J ±  kb
transcript NM_025848 RefSeq | MGI Sequence Detail 1287 C57BL/6 
polypeptide Q9CXV1 UniProt | EBI | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007992 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
Protein Ontology PR:000014566 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:212339 Millan-Ucles A, et al., A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction. PLoS One. 2014;9(1):e85528
All references(50)
Other
accession IDs
MGI:2143396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory