Wwp2
Gene Detail

Symbol Name ID

Wwp2 WW domain containing E3 ubiquitin protein ligase 2 MGI:1914144

Synonyms

1300010O06Rik, AIP2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

54.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:107436398-107558594 bp, + strand From Ensembl annotation of GRCm38   122197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Wwp2

Human homologs

Human Homolog		WWP2, WW domain containing E3 ubiquitin protein ligase 2
NCBI Gene ID		11060
neXtProt AC		NX_O00308
Human Synonyms		AIP2, WWp2-like
Human Chr (Location)		16q22.1; chr16:69796187-69975644 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(475) : Gene trapped(475)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	negative regulation of gene expression, negative regulation of protein transport, ...
Component	cytoplasm, nucleus
Function	ligase activity, RNA polymerase II transcription factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (350)    Tissues (49)    Images (31)
Theiler Stages: 15, 19, 21, 23

Assay Type	Results
RNA in situ	350

cDNA source data(178)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(178) cDNA(178)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031930 (Evidence)
Entrez Gene	66894 (Evidence)
UniGene	390058
DFCI	TC1572000, TC1601434, TC1603279, TC1608189, TC1633374
DoTS	DT.101178892, DT.101180686, DT.101230486, DT.110850477, DT.110850500, DT.530254, DT.91336076, DT.91439871
EC	6.3.2.-
Consensus CDS Project	CCDS40467.1
International Mouse Knockout Project Status	Wwp2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031930	Ensembl Gene Model | MGI Sequence Detail	122197	C57BL/6J
transcript	ENSMUST00000166615	Ensembl | MGI Sequence Detail	4280	Not Applicable
polypeptide	ENSMUSP00000132224	Ensembl | MGI Sequence Detail	870	Not Applicable

All sequences(60) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(172 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000017465	NEDD4-like E3 ubiquitin-protein ligase WWP2

References

(Earliest) J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
(Latest) J:176426 Yang J, et al., MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 2011 Oct 3;585(19):2992-7
All references(41)

Other accession IDs

MGI:2142444, MGI:2142806