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Wwp2
Gene Detail
Symbol

Name
ID
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
MGI:1914144
Synonyms
1300010O06Rik, AIP2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
54.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:107436398-107558594 bp, + strand
From Ensembl annotation of GRCm38

  122197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WWP2
Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Wwp2

Human
homologs
WWP2, WW domain containing E3 ubiquitin protein ligase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11060
neXtProt AC: NX_O00308

Human Synonyms: AIP2, WWp2-like

Human Chr (Location): 16q22.1; chr16:69762284-69941741 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(475) : Gene trapped(475)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Wwp2 interacts with 188 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (351)    Tissues (50)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 351
cDNA source data(181)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WWP2 ; Xenbase wwp2 ; ZFIN wwp2    NEW 
Molecular
reagents
All nucleic(181) cDNA(181)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000031930 (Evidence)
Entrez Gene 66894 (Evidence)
UniGene 390058
DFCI TC1601434, TC1572000, TC1633374, TC1603279, TC1608189
DoTS DT.91336076, DT.530254, DT.110850500, DT.101178892, DT.110850477, DT.101230486, DT.101180686, DT.91439871
EC 6.3.2.-
Consensus CDS Project CCDS40467.1
International Mouse Phenotyping Consortium Status Wwp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031930 Ensembl Gene Model | MGI Sequence Detail 122197 C57BL/6J ±  kb
transcript ENSMUST00000166615 Ensembl | MGI Sequence Detail 4280 Not Applicable 
polypeptide ENSMUSP00000132224 Ensembl | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000017465 NEDD4-like E3 ubiquitin-protein ligase WWP2
References
(Earliest) J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
(Latest) J:216214 Raspopovic J, et al., Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science. 2014 Aug 1;345(6196):566-70
All references(42)
Other
accession IDs
MGI:2142444, MGI:2142806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory