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Wwp2
Gene Detail
 Symbol
Name
ID
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
MGI:1914144
Synonyms 1300010O06Rik, AIP2
Feature Type protein coding gene
Genetic Map
Chromosome 8
54.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:107436398-107558594 bp, + strand
From Ensembl annotation of GRCm38

  122197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Wwp2

Human
homologs
Human Homolog WWP2, WW domain containing E3 ubiquitin protein ligase 2
NCBI Gene ID 11060
neXtProt AC  NX_O00308
Human Synonyms  AIP2, WWp2-like
Human Chr (Location)  16q22.1; chr16:69762284-69941741 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(475) : Gene trapped(475)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Wwp2 interacts with 189 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process negative regulation of gene expression, negative regulation of protein transport, ...
Component cytoplasm, membrane, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (351)    Tissues (50)    Images (31)
Theiler Stages: 15, 19, 21, 23
Assay TypeResults
RNA in situ 351
cDNA source data(181)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) cDNA(181)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031930 (Evidence)
Entrez Gene66894 (Evidence)
UniGene390058
DFCITC1572000, TC1601434, TC1603279, TC1608189, TC1633374
DoTSDT.101178892, DT.101180686, DT.101230486, DT.110850477, DT.110850500, DT.530254, DT.91336076, DT.91439871
EC6.3.2.-
Consensus CDS ProjectCCDS40467.1
International Mouse Knockout Project StatusWwp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031930 Ensembl Gene Model | MGI Sequence Detail 122197 C57BL/6J ±  kb
transcript ENSMUST00000166615 Ensembl | MGI Sequence Detail 4280 Not Applicable 
polypeptide ENSMUSP00000132224 Ensembl | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000017465 NEDD4-like E3 ubiquitin-protein ligase WWP2
References (Earliest) J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
(Latest) J:176426 Yang J, et al., MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 2011 Oct 3;585(19):2992-7
All references(42)
Other
accession IDs
MGI:2142444, MGI:2142806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory