Pnpla2
Gene Detail

Symbol Name ID

Pnpla2 patatin-like phospholipase domain containing 2 MGI:1914103

Synonyms

0610039C21Rik, 1110001C14Rik, Atgl, desnutrin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.81 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:141455198-141460743 bp, + strand From VEGA annotation of GRCm38   5546 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pnpla2

Human homologs

Human Homolog		PNPLA2, patatin-like phospholipase domain containing 2
NCBI Gene ID		57104
neXtProt AC		NX_Q96AD5
Human Synonyms		1110001C14Rik, ATGL, iPLA2zeta, PEDF-R, TTS2, TTS-2.2
Human Chr (Location)		11p15.5; chr11:818901-825573 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PNPLA2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for this targeted mutation have defects in lipolysis and altered energy metabolism. Triglyceride accumulation in cardiac muscle leads to severe cardiac dysfunction and mortality.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	lipid catabolic process, lipid metabolic process, ...
Component	cytosol, integral to membrane, ...
Function	hydrolase activity, protein binding, ...

External Resources: FuncBase

Expression

cDNA source data(200)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(200) cDNA(200)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035378 (Evidence)
Ensembl Gene Model	ENSMUSG00000025509 (Evidence)
Entrez Gene	66853 (Evidence)
UniGene	29998
DFCI	TC1572629, TC1595844, TC1598074, TC1599711, TC1658365
DoTS	DT.101242443, DT.101381420, DT.101736496, DT.101736498, DT.91359355
NIA Mouse Gene Index	U008961, U029461
EC	3.1.1.3
Consensus CDS Project	CCDS22015.1, CCDS52445.1
International Mouse Knockout Project Status	Pnpla2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035378	VEGA Gene Model | MGI Sequence Detail	5546	C57BL/6J
transcript	OTTMUST00000090404	VEGA | MGI Sequence Detail	2625	Not Applicable
polypeptide	OTTMUSP00000049587	VEGA | MGI Sequence Detail	486	Not Applicable

All sequences(82) RefSeq(5) UniProt(5)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
InterPro	IPR002641	Patatin/Phospholipase A2-related
Protein Ontology	PR:000012942	patatin-like phospholipase domain-containing protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193091 Obrowsky S, et al., Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARalpha signaling. J Lipid Res. 2013 Feb;54(2):425-35
All references(61)

Other accession IDs

MGI:1915801