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Bcs1l
Gene Detail
Symbol

Name
ID
Bcs1l
BCS1-like (yeast)
MGI:1914071
Synonyms
9130022O19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74588289-74592443 bp, + strand
From VEGA annotation of GRCm38

  4155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcs1l

Human
homologs
Human Homolog BCS1L, BC1 (ubiquinol-cytochrome c reductase) synthesis-like
NCBI Gene ID 617
neXtProt AC  NX_Q9Y276
Human Synonyms  BCS, BCS1, BJS, FLNMS, GRACILE, h-BCS, Hs.6719, MC3DN1, PTD
Human Chr (Location)  2q33; chr2:218659656-218663443 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human BCS1L
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit reduced growth, defects in the liver, kidney and testes, and mitochondrial hepatopathy with premature death.
 
Human Diseases Modeled Using Mouse Bcs1l (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Bcs1l interacts with 56 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (125)    Tissues (88)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 118
RNA in situ 5
Western blot 2
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021745 (Evidence)
Ensembl Gene ModelENSMUSG00000026172 (Evidence)
Entrez Gene66821 (Evidence)
UniGene358700
DFCITC1580191
DoTSDT.529171
NIA Mouse Gene IndexU000455
Consensus CDS ProjectCCDS15051.1
International Mouse Knockout Project StatusBcs1l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021745 VEGA Gene Model | MGI Sequence Detail 4155 C57BL/6J ±  kb
transcript OTTMUST00000051601 VEGA | MGI Sequence Detail 1488 Not Applicable 
polypeptide OTTMUSP00000024321 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR014851 BCS1, N-terminal
InterPro IPR027243 Mitochondrial chaperone BCS1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000004713 mitochondrial chaperone BCS1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212727 Davoudi M, et al., Complex I function and supercomplex formation are preserved in liver mitochondria despite progressive complex III deficiency. PLoS One. 2014;9(1):e86767
All references(34)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory