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Nipbl
Gene Detail
Symbol

Name
ID
Nipbl
Nipped-B homolog (Drosophila)
MGI:1913976
Synonyms
4921518A06Rik, 4933421G18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.82 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:8291225-8444463 bp, - strand
From Ensembl annotation of GRCm38

  153239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NIPBL
Gene Tree: Nipbl

Human
homologs
NIPBL, Nipped-B homolog (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25836
neXtProt AC: NX_Q6KC79

Human Synonyms: CDLS, CDLS1, IDN3, IDN3-B, Scc2

Human Chr (Location): 5p13.2; chr5:36876759-37065819 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NIPBL

Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Gene trapped(65) Targeted(4) Transposon induced(1)
Genomic Mutations involving Nipbl (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Human Diseases Modeled in Mice Using Nipbl (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Nipbl interacts with 2 markers (Mir151, Mir323)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process brain development, cell cycle, ...
Component chromatin, extracellular exosome, ...
Function chromatin binding, chromo shadow domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (95)    Tissues (95)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nipbl ; ZFIN nipbla, nipblb    NEW 
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022141 (Evidence)
Entrez Gene 71175 (Evidence)
DFCI TC1650523, TC1628193, TC1589035, TC1612801, TC1584757, TC1600329, TC1598645, TC1576495
DoTS DT.40175078, DT.101337782, DT.103568542, DT.60102623, DT.94144068, DT.91399466, DT.91394210, DT.489170, DT.94188114, DT.99571425
NIA Mouse Gene Index U043877
Consensus CDS Project CCDS37035.1
International Mouse Phenotyping Consortium Status Nipbl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022141 Ensembl Gene Model | MGI Sequence Detail 153239 C57BL/6J ±  kb
transcript ENSMUST00000052965 Ensembl | MGI Sequence Detail 8815 Not Applicable 
polypeptide ENSMUSP00000059385 Ensembl | MGI Sequence Detail 2798 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(252 from dbSNP Build 137)    SNPs within 2kb including multiple locations(256)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR026003 HEAT repeat associated with sister chromatid cohesion protein
InterPro IPR024986 Sister chromatid cohesion C-terminal domain
Protein Ontology PR:000011219 nipped-B-like protein
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:213338 Smith TG, et al., Neural crest cell-specific inactivation of Nipbl or Mau2 during mouse development results in a late onset of craniofacial defects. Genesis. 2014 Jul;52(7):687-94
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:1918425, MGI:2146291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory