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Lrrk2 Gene Detail
Summary
  • Symbol
    Lrrk2
  • Name
    leucine-rich repeat kinase 2
  • Synonyms
    4921513O20Rik, 9330188B09Rik, cI-46, D630001M17Rik, LOC381026
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913975
    NCBI Gene: 66725
  • Gene Overview
    MyGene.info: LRRK2
Location & Maps
more
  • Sequence Map
    Chr15:91673175-91816120 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142946 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 46.07 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LRRK2, leucine rich repeat kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRK2, leucine rich repeat kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AURA17, DARDARIN, PARK8, RIPK7, ROCO2
  • Links
    NCBI Gene ID: 120892
    neXtProt AC: NX_Q5S007

  • Chr Location
    12q12; chr12:40225011-40369285 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18982
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRK2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrrk2 mouse models; 1 with human LRRK2 associations

Human Disease Mouse Models
       Parkinson Disease 8, Autosomal Dominant; PARK8   OMIM: 607060 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 17 alleles in 12 genetic backgrounds
    40 phenotypes from multigenic genotypes
    6 images
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    21
  • Transgenic
    18
  • Genomic Mutations
    3 involving Lrrk2
  • Incidental Mutations
Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020864 VEGA Gene Model | MGI Sequence Detail 142946 C57BL/6J ±  kb
transcript OTTMUST00000049323 VEGA | MGI Sequence Detail 8275 Not Applicable  
polypeptide OTTMUSP00000022827 VEGA | MGI Sequence Detail 2527 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    935 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 26
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1930800, MGI:2442391, MGI:2685773
References
more
  • Summaries
    All 99
    Developmental Gene Expression 4
    Diseases 11
    Gene Ontology 25
    Phenotypes 84
  • Earliest
    J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
  • Latest
    J:235302 Guaitoli G, et al., Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory