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Lrrk2
Gene Detail
Symbol

Name
ID
Lrrk2
leucine-rich repeat kinase 2
MGI:1913975
Synonyms
4921513O20Rik, 9330188B09Rik, cI-46, D630001M17Rik, LOC381026
Feature Type
protein coding gene
Genetic Map
Chromosome 15
46.07 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:91673175-91816120 bp, + strand
From VEGA annotation of GRCm38

  142946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRRK2
Gene Tree: Lrrk2

Human
homologs
LRRK2, leucine-rich repeat kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 120892
neXtProt AC: NX_Q5S007

Human Synonyms: AURA17, DARDARIN, PARK8, RIPK7, ROCO2

Human Chr (Location): 12q12; chr12:40225011-40369285 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRRK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Radiation induced(1) Targeted(18) Transgenic(17)
Genomic Mutations involving Lrrk2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.
 
Human Diseases Modeled in Mice Using Lrrk2 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(2)
Interactions
Lrrk2 interacts with 204 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (153 annotations)
Process activation of MAPK activity, activation of MAPKK activity, ...
Component axon, cell, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (39)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 22
Western blot 43
RT-PCR 20
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lrrk2 ; ZFIN lrrk2    NEW 
Molecular
reagents
All nucleic(28) cDNA(26) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020864 (Evidence)
Ensembl Gene Model ENSMUSG00000036273 (Evidence)
Entrez Gene 66725 (Evidence)
UniGene 37558
DFCI TC1588429, TC1584532, TC1597475, TC1664605
DoTS DT.91280131, DT.60105160, DT.101703599, DT.101366351, DT.94148775, DT.91413521
NIA Mouse Gene Index U043472
EC 2.7.11.1
Consensus CDS Project CCDS37180.1
International Mouse Phenotyping Consortium Status Lrrk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020864 VEGA Gene Model | MGI Sequence Detail 142946 C57BL/6J ±  kb
transcript OTTMUST00000049323 VEGA | MGI Sequence Detail 8275 Not Applicable 
polypeptide OTTMUSP00000022827 VEGA | MGI Sequence Detail 2527 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(955 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR013684 Mitochondrial Rho-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020859 ROC GTPase
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001806 Small GTPase superfamily
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000003033 leucine-rich repeat serine/threonine-protein kinase 2
References
(Earliest) J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
(Latest) J:221458 Caesar M, et al., Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers. Neuroscience. 2015 Jan 22;284:311-24
All references(93)
Disease annotation references (1)
Other
accession IDs
MGI:1930800, MGI:2442391, MGI:2685773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory