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Lrrk2
Gene Detail
Symbol

Name
ID
Lrrk2
leucine-rich repeat kinase 2
MGI:1913975
Synonyms
4921513O20Rik, 9330188B09Rik, cI-46, D630001M17Rik, LOC381026
Feature Type
protein coding gene
Genetic Map
Chromosome 15
46.07 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:91673175-91816120 bp, + strand
From VEGA annotation of GRCm38

  142946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrrk2

Human
homologs
Human Homolog LRRK2, leucine-rich repeat kinase 2
NCBI Gene ID 120892
neXtProt AC  NX_Q5S007
Human Synonyms  AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Human Chr (Location)  12q12; chr12:40225011-40369285 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRRK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Radiation induced(1) Targeted(16)
Genomic Mutations involving Lrrk2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.
 
Interactions
Lrrk2 interacts with 204 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (127 annotations)
Process activation of MAPK activity, activation of MAPKK activity, ...
Component axon, cell projection, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (85)    Tissues (39)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 22
Western blot 43
RT-PCR 20
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(26) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020864 (Evidence)
Ensembl Gene ModelENSMUSG00000036273 (Evidence)
Entrez Gene66725 (Evidence)
UniGene37558
DFCITC1664605, TC1597475, TC1584532, TC1588429
DoTSDT.91280131, DT.60105160, DT.101703599, DT.101366351, DT.94148775, DT.91413521
NIA Mouse Gene IndexU043472
EC2.7.11.1
Consensus CDS ProjectCCDS37180.1
International Mouse Knockout Project StatusLrrk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020864 VEGA Gene Model | MGI Sequence Detail 142946 C57BL/6J ±  kb
transcript OTTMUST00000049323 VEGA | MGI Sequence Detail 8275 Not Applicable 
polypeptide OTTMUSP00000022827 VEGA | MGI Sequence Detail 2527 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(955 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR013684 Mitochondrial Rho-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020859 ROC GTPase
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001806 Small GTPase superfamily
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000003033 leucine-rich repeat serine/threonine-protein kinase 2
References
(Earliest) J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
(Latest) J:213877 Dusonchet J, et al., A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Hum Mol Genet. 2014 Sep 15;23(18):4887-905
All references(86)
Other
accession IDs
MGI:1930800, MGI:2442391, MGI:2685773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory