Tg(Lrrk2*G2019S)2Yue
Transgene Detail

Summary

• Symbol: Tg(Lrrk2*G2019S)2Yue
• Name: transgene insertion 2, Zhenyu Yue
• MGI ID: MGI:4437428
• Synonyms: FLAG-LRRK2-G2019S, LRRK2-G2019S^OE
• Transgene: Tg(Lrrk2*G2019S)2Yue Location: Chr18:45101152-45101153 bp Genetic Position: Chr18, Syntenic
• Alliance: Tg(Lrrk2*G2019S)2Yue page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lrrk2*G2019S)2Yue expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lrrk2 (MGI:1913975)

• Mutation details: A bacterial artificial chromosome (BAC) (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the Lrrk2 locus to harbor the Lrrk2-G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. This modified 240 kb BAC contains a FLAG-tag downstream from the start codon. Line 2 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2. (J:128036)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128036 Li X, et al., Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem. 2007 Oct;103(1):238-47
• All: 17 reference(s)