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Aspn Gene Detail
Summary
  • Symbol
    Aspn
  • Name
    asporin
  • Synonyms
    4631401G09Rik, PLAP-1, SLRR1C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913945
    NCBI Gene: 66695
  • Gene Overview
    MyGene.info: ASPN
Location & Maps
more
  • Sequence Map
    Chr13:49544443-49567557 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23115 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ASPN, asporin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ASPN, asporin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OS3, PLAP1, PLAP-1, SLRR1C
  • Links
    NCBI Gene ID: 54829
    neXtProt AC: NX_Q9BXN1

  • Chr Location
    9q22; chr9:92456205-92482562 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ASPN associations

Human Disease Mouse Models
       Intervertebral Disc Disease; IDD   OMIM: 603932
Osteoarthritis Susceptibility 3; OS3   OMIM: 607850
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Aspn
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021388 Ensembl Gene Model | MGI Sequence Detail 23115 C57BL/6J ±  kb
transcript ENSMUST00000021820 Ensembl | MGI Sequence Detail 2346 Not Applicable  
polypeptide ENSMUSP00000021820 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004382 asporin
  • InterPro Domains
    IPR028548 Asporin
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145178
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217339 Beiser KU, et al., Identification of novel SHOX target genes in the developing limb using a transgenic mouse model. PLoS One. 2014;9(6):e98543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory