Homozygotes are viable and fertile with no gross morphological or histological abnormalities. Normal induction of apoptosis in UV-irradiated or Fas-antibody treated cells was noted, and these mice also exhibit normal T and B cell proliferative responses.
|Process||activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ...|
|Component||CD40 receptor complex, cytoplasm, ...|
|VEGA Gene Model||OTTMUSG00000025948 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000029433 (Evidence)|
|Entrez Gene||66593 (Evidence)|
|DFCI||TC1779859, TC1588139, TC1575539, TC1714707, TC1633234|
|NIA Mouse Gene Index||U158330|
|Consensus CDS Project||CCDS39270.1|
|International Mouse Phenotyping Consortium Status||Diablo|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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