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Crls1 Gene Detail
Summary
  • Symbol
    Crls1
  • Name
    cardiolipin synthase 1
  • Synonyms
    0610009I22Rik, 4930557M15Rik, 5730490M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913836
    NCBI Gene: 66586
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132846666-132866785 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.77 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913836
protein coding gene Chr2:132846652-132866786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026548
protein coding gene Chr2:136475999-136497957 (+)
A/J MGP_AJ_G0026512
protein coding gene Chr2:130905152-130926086 (+)
AKR/J MGP_AKRJ_G0026486
protein coding gene Chr2:134694124-134714991 (+)
BALB/cJ MGP_BALBcJ_G0026524
protein coding gene Chr2:131312830-131333841 (+)
C3H/HeJ MGP_C3HHeJ_G0026267
protein coding gene Chr2:135131146-135151260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026969
protein coding gene Chr2:140625321-140647127 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024346
protein coding gene Chr2:125629729-125652062 (+)
CAST/EiJ MGP_CASTEiJ_G0025728
protein coding gene Chr2:135469961-135490235 (+)
CBA/J MGP_CBAJ_G0026247
protein coding gene Chr2:145902032-145922197 (+)
DBA/2J MGP_DBA2J_G0026381
protein coding gene Chr2:130291020-130311011 (+)
FVB/NJ MGP_FVBNJ_G0026345
protein coding gene Chr2:128923892-128943878 (+)
LP/J MGP_LPJ_G0026485
protein coding gene Chr2:136705287-136726493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026365
protein coding gene Chr2:149620750-149641915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027024
protein coding gene Chr2:134656786-134676815 (+)
PWK/PhJ MGP_PWKPhJ_G0025464
protein coding gene Chr2:129907308-129928061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025266
protein coding gene Chr2:133817638-133842520 (+)
WSB/EiJ MGP_WSBEiJ_G0025802
protein coding gene Chr2:135578082-135601854 (+)



Homology
more
  • Human Ortholog
    CRLS1, cardiolipin synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRLS1, cardiolipin synthase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf155, CLS, CLS1, dJ967N21.6, GCD10
  • Links
    NCBI Gene ID: 54675
    neXtProt AC: NX_Q9UJA2
    UniProt: Q9UJA2

  • Chr Location
    20p12.3; chr20:6005938-6040053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Crls1
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027357 Ensembl Gene Model | MGI Sequence Detail 20120 C57BL/6J ±  kb
transcript ENSMUST00000028835 Ensembl | MGI Sequence Detail 1924 Not Applicable  
polypeptide ENSMUSP00000028835 Ensembl | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917885, MGI:1922621
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:266083 Sustarsic EG, et al., Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metab. 2018 Jul 3;28(1):159-174.e11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory