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Crls1 Gene Detail
Summary
  • Symbol
    Crls1
  • Name
    cardiolipin synthase 1
  • Synonyms
    0610009I22Rik, 4930557M15Rik, 5730490M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913836
    NCBI Gene: 66586
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:132846666-132866785 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20120 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.77 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRLS1, cardiolipin synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRLS1, cardiolipin synthase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf155, CLS, CLS1, dJ967N21.6, GCD10
  • Links
    NCBI Gene ID: 54675
    neXtProt AC: NX_Q9UJA2
    UniProt: Q9UJA2

  • Chr Location
    20p12.3; chr20:6005938-6040053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Crls1
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015664 VEGA Gene Model | MGI Sequence Detail 20120 C57BL/6J ±  kb
transcript OTTMUST00000037217 VEGA | MGI Sequence Detail 1924 Not Applicable  
polypeptide OTTMUSP00000016677 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    84 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917885, MGI:1922621
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:211821 Chen BB, et al., E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Rep. 2014 Apr 24;7(2):476-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory