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Ptpmt1
Gene Detail
Symbol

Name
ID
Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
MGI:1913711
Synonyms
1110001D10Rik, 2810004N20Rik, PLIP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:90908716-90918258 bp, - strand
From VEGA annotation of GRCm38

  9543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPMT1
Gene Tree: Ptpmt1

Human
homologs
PTPMT1, protein tyrosine phosphatase, mitochondrial 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 114971
neXtProt AC: NX_Q8WUK0

Human Synonyms: DUSP23, MOSP, PLIP, PNAS-129

Human Chr (Location): 11p11.2; chr11:47565430-47573461 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(11) Targeted(8)
Genomic Mutations involving Ptpmt1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null alleles die between implantation and E8.5
 
Interactions
Ptpmt1 interacts with 131 markers (Mir18, Mir22, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cardiolipin biosynthetic process, dephosphorylation, ...
Component integral component of mitochondrial inner membrane, membrane, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RT-PCR 13
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(56) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014318 (Evidence)
Ensembl Gene Model ENSMUSG00000063235 (Evidence)
Entrez Gene 66461 (Evidence)
UniGene 23926
DFCI TC1580007, TC1603472
DoTS DT.533086, DT.55117346, DT.91336970
NIA Mouse Gene Index U023010
EC 3.1.3.16, 3.1.3.27, 3.1.3.48
PDB 3RGO, 3RGQ
International Mouse Phenotyping Consortium Status Ptpmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014318 VEGA Gene Model | MGI Sequence Detail 9543 C57BL/6J ±  kb
transcript NM_025576 RefSeq | MGI Sequence Detail 1322 C57BL/6 
polypeptide Q66GT5 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
Protein Ontology PR:000013447 protein-tyrosine phosphatase mitochondrial 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194929 Yu WM, et al., Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013 Jan 3;12(1):62-74
All references(40)
Other
accession IDs
MGI:1915707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory