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Ptpmt1
Gene Detail
 Symbol
Name
ID
Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
MGI:1913711
BioType Conflict
Synonyms 1110001D10Rik, 2810004N20Rik, PLIP
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.44 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:90908716-90918258 bp, - strand
From VEGA annotation of GRCm38

  9543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptpmt1

Human
homologs
Human Homolog PTPMT1, protein tyrosine phosphatase, mitochondrial 1
NCBI Gene ID 114971
neXtProt AC  NX_Q8WUK0
Human Synonyms  DUSP23, MOSP, PLIP
Human Chr (Location)  11p11.2; chr11:47565430-47573461 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(11) Targeted(8)
Genomic Mutations involving Ptpmt1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null alleles die between implantation and E8.5
 
Interactions
Ptpmt1 interacts with 131 markers (Mir18, Mir22, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cardiolipin biosynthetic process, dephosphorylation, ...
Component integral component of mitochondrial inner membrane, membrane, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (15)   
Theiler Stages: 5, 11, 28
Assay TypeResults
Immunohistochemistry 5
RT-PCR 13
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(56) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014318 (Evidence)
Ensembl Gene ModelENSMUSG00000063235 (Evidence)
Entrez Gene66461 (Evidence)
UniGene23926
DFCITC1580007, TC1603472
DoTSDT.533086, DT.55117346, DT.91336970
NIA Mouse Gene IndexU023010
EC3.1.3.16, 3.1.3.27, 3.1.3.48
PDB3RGO, 3RGQ
International Mouse Knockout Project StatusPtpmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014318 VEGA Gene Model | MGI Sequence Detail 9543 C57BL/6J ±  kb
transcript OTTMUST00000033784 VEGA | MGI Sequence Detail 3183 Not Applicable 
polypeptide Q66GT5 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
Protein Ontology PR:000013447 protein-tyrosine phosphatase mitochondrial 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194929 Yu WM, et al., Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013 Jan 3;12(1):62-74
All references(41)
Other
accession IDs
MGI:1915707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory