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Aqp11 Gene Detail
Summary
  • Symbol
    Aqp11
  • Name
    aquaporin 11
  • Synonyms
    1700015P13Rik, sjds
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913583
    NCBI Gene: 66333
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97726379-97738247 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913583
protein coding gene Chr7:97724006-97738289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032530
protein coding gene Chr7:100432104-100446417 (-)
A/J MGP_AJ_G0032504
protein coding gene Chr7:97943067-97957384 (-)
AKR/J MGP_AKRJ_G0032440
protein coding gene Chr7:100279856-100294162 (-)
BALB/cJ MGP_BALBcJ_G0032515
protein coding gene Chr7:97632769-97647078 (-)
C3H/HeJ MGP_C3HHeJ_G0032230
protein coding gene Chr7:100630435-100644824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033013
protein coding gene Chr7:104344080-104358363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030008
protein coding gene Chr7:100390383-100405178 (-)
CAST/EiJ MGP_CASTEiJ_G0031557
protein coding gene Chr7:92152680-92167013 (-)
CBA/J MGP_CBAJ_G0032197
protein coding gene Chr7:107865234-107879606 (-)
DBA/2J MGP_DBA2J_G0032349
protein coding gene Chr7:96299738-96314123 (-)
FVB/NJ MGP_FVBNJ_G0032305
protein coding gene Chr7:96090985-96105263 (-)
LP/J MGP_LPJ_G0032438
protein coding gene Chr7:101752348-101766662 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032338
protein coding gene Chr7:109401230-109420473 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033035
protein coding gene Chr7:99560217-99574521 (-)
PWK/PhJ MGP_PWKPhJ_G0031275
protein coding gene Chr7:89360957-89376186 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031118
protein coding gene Chr7:86804100-86818410 (-)
WSB/EiJ MGP_WSBEiJ_G0031674
protein coding gene Chr7:100202158-100216804 (-)



Homology
more
  • Human Ortholog
    AQP11, aquaporin 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AQP11, aquaporin 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AQPX1
  • Links
    NCBI Gene ID: 282679
    neXtProt AC: NX_Q8NBQ7
    UniProt: Q8NBQ7

  • Chr Location
    11q14.1; chr11:77589635-77610356 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 7 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display premature death, kidney failure, polycystic kidneys with cysts originating from the proximal tubules, and growth retardation. Mice homozygous for an ENU-induced mutation are apparently healthy but exhibit sudden death between2 and 3 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66333 NCBI Gene Model | MGI Sequence Detail 11869 C57BL/6J ±  kb
    transcript NM_175105 RefSeq | MGI Sequence Detail 1322 C57BL/6  
    polypeptide Q8BHH1 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1338787, MGI:2142021
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 33
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:250201 Tanahashi H, et al., Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016 Feb 5;6:20241

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory