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Smurf2 Gene Detail
Summary
  • Symbol
    Smurf2
  • Name
    SMAD specific E3 ubiquitin protein ligase 2
  • Synonyms
    2810411E22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913563
    NCBI Gene: 66313
  • Gene Overview
    MyGene.info: SMURF2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106820066-106920715 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 70.03 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913563
protein coding gene Chr11:106820061-106920715 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019315
protein coding gene Chr11:110157724-110269796 (-)
A/J MGP_AJ_G0019283
protein coding gene Chr11:105452922-105555300 (-)
AKR/J MGP_AKRJ_G0019252
protein coding gene Chr11:108595412-108701613 (-)
BALB/cJ MGP_BALBcJ_G0019257
protein coding gene Chr11:105868750-105969132 (-)
C3H/HeJ MGP_C3HHeJ_G0019066
protein coding gene Chr11:108890493-108994008 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019707
protein coding gene Chr11:113559098-113671381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017331
protein coding gene Chr11:102722255-102826760 (-)
CAST/EiJ MGP_CASTEiJ_G0018619
protein coding gene Chr11:109979365-110086234 (-)
CBA/J MGP_CBAJ_G0019035
protein coding gene Chr11:118259125-118365818 (-)
DBA/2J MGP_DBA2J_G0019147
protein coding gene Chr11:104922649-105023806 (-)
FVB/NJ MGP_FVBNJ_G0019138
protein coding gene Chr11:104436763-104537669 (-)
LP/J MGP_LPJ_G0019217
protein coding gene Chr11:110607807-110710685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019168
protein coding gene Chr11:117501719-117609984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019744
protein coding gene Chr11:109116468-109221145 (-)
PWK/PhJ MGP_PWKPhJ_G0018384
protein coding gene Chr11:106038139-106146955 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018175
protein coding gene Chr11:108888169-108996594 (-)
WSB/EiJ MGP_WSBEiJ_G0018670
protein coding gene Chr11:109091144-109193860 (-)



Homology
more
  • Human Ortholog
    SMURF2, SMAD specific E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SMURF2, SMAD specific E3 ubiquitin protein ligase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64750
    neXtProt AC: NX_Q9HAU4
    UniProt: Q9HAU4

  • Chr Location
    17q23.3-q24.1; chr17:64542282-64662268 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele occasionally exhibit kinked or looped tails and abnormal vertebrae. Mice homozygous or heterozygous for a gene trap allele exhibit increased tumor incidence and delayed cellular senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018363 Ensembl Gene Model | MGI Sequence Detail 100650 C57BL/6J ±  kb
    transcript ENSMUST00000092517 Ensembl | MGI Sequence Detail 3125 Not Applicable  
    polypeptide ENSMUSP00000090177 Ensembl | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 140
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2144225, MGI:2144252
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264118 Papoutsi T, et al., Bmp2 and Notch cooperate to pattern the embryonic endocardium. Development. 2018 Jul 2;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory