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Smurf2
Gene Detail
 Symbol
Name
ID
Smurf2
SMAD specific E3 ubiquitin protein ligase 2
MGI:1913563
Synonyms 2810411E22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
70.03 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:106820066-106920715 bp, - strand
From VEGA annotation of GRCm38

  100650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Smurf2

Human
homologs
Human Homolog SMURF2, SMAD specific E3 ubiquitin protein ligase 2
NCBI Gene ID 64750
neXtProt AC  NX_Q9HAU4
Human Chr (Location)  17q22-q23; chr17:64542282-64662268 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele occasionally exhibit kinked or looped tails and abnormal vertebrae. Mice homozygous or heterozygous for a gene trap allele exhibit increased tumor incidence and delayed cellular senescence.
 
Interactions
Smurf2 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process protein ubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, ...
Component cytoplasm, membrane, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(140) cDNA(139) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000003584 (Evidence)
Ensembl Gene ModelENSMUSG00000018363 (Evidence)
Entrez Gene66313 (Evidence)
UniGene340955
DFCITC1580868, TC1599799, TC1696124
DoTSDT.101386141, DT.40158948, DT.489666, DT.55178760
NIA Mouse Gene IndexU033550
EC6.3.2.-
Consensus CDS ProjectCCDS25564.1
International Mouse Knockout Project StatusSmurf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003584 VEGA Gene Model | MGI Sequence Detail 100650 C57BL/6J ±  kb
transcript OTTMUST00000007723 VEGA | MGI Sequence Detail 3125 Not Applicable 
polypeptide OTTMUSP00000003747 VEGA | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(246 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000000362 E3 ubiquitin-protein ligase SMURF2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196581 Gui T, et al., The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Dev Biol. 2013 May 15;377(2):415-27
All references(54)
Other
accession IDs
MGI:2144225, MGI:2144252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory