Smurf2
Gene Detail

Symbol Name ID

Smurf2 SMAD specific E3 ubiquitin protein ligase 2 MGI:1913563

Synonyms

2810411E22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

70.03 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:106820066-106920715 bp, - strand From VEGA annotation of GRCm38   100650 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Smurf2

Human homologs

Human Homolog		SMURF2, SMAD specific E3 ubiquitin protein ligase 2
NCBI Gene ID		64750
neXtProt AC		NX_Q9HAU4
Human Chr (Location)		17q22-q23; chr17:62540735-62658386 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(4) Gene trapped(7)
 

Mice homozygous for a knock-out allele occasionally exhibit kinked or looped tails and abnormal vertebrae. Mice homozygous or heterozygous for a gene trap allele exhibit increased tumor incidence and delayed cellular senescence.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	protein ubiquitination involved in ubiquitin-dependent protein catabolic process, transforming growth factor beta receptor signaling pathway, ...
Component	cytoplasm, membrane, ...
Function	identical protein binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(136) cDNA(135) Primer pair(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000003584 (Evidence)
Ensembl Gene Model	ENSMUSG00000018363 (Evidence)
Entrez Gene	66313 (Evidence)
UniGene	340955
DFCI	TC1580868, TC1599799, TC1696124
DoTS	DT.101386141, DT.40158948, DT.489666, DT.55178760
NIA Mouse Gene Index	U033550
EC	6.3.2.-
Consensus CDS Project	CCDS25564.1
International Mouse Knockout Project Status	Smurf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003584	VEGA Gene Model | MGI Sequence Detail	100650	C57BL/6J
transcript	OTTMUST00000007723	VEGA | MGI Sequence Detail	3125	Not Applicable
polypeptide	OTTMUSP00000003747	VEGA | MGI Sequence Detail	748	Not Applicable

All sequences(58) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(184 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000000362	smad ubiquitination regulatory factor 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189320 Ramkumar C, et al., Smurf2 regulates the senescence response and suppresses tumorigenesis in mice. Cancer Res. 2012 Jun 1;72(11):2714-9
All references(50)

Other accession IDs

MGI:2144225, MGI:2144252