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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smurf2
SMAD specific E3 ubiquitin protein ligase 2
MGI:1913563
15 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Smurf2Gt(RRA098)Byg/\Smurf2+
involves: 129P2/OlaHsd * C57BL/6 		delayed cellular replicative senescence J:189320
increased lymphoma incidence J:189320
increased tumor incidence J:189320
\Smurf2Gt(RRA098)Byg/\Smurf2Gt(RRA098)Byg
involves: 129P2/OlaHsd * C57BL/6 		delayed cellular replicative senescence J:189320
enlarged spleen J:189320
increased B cell derived lymphoma incidence J:189320, J:245679
increased hepatocellular carcinoma incidence J:189320
increased lymphoma incidence J:189320
increased sarcoma incidence J:189320
increased small intestine adenocarcinoma incidence J:189320
increased tumor incidence J:189320
\Smurf2tm1b(EUCOMM)Wtsi/\Smurf2tm1b(EUCOMM)Wtsi
C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H 		preweaning lethality, incomplete penetrance J:211773
\Smurf2tm1Wran/\Smurf2tm1Wran
involves: 129S1/Sv * 129X1/SvJ * ICR 		no abnormal phenotype detected J:148693
\Smurf2tm1Yez/\Smurf2tm1Yez
either: B6.129S6-Smurf2tm1Yez or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal cell physiology J:180221
abnormal tail morphology J:180221
abnormal vertebrae morphology J:180221
hydrocephaly J:180221
kinked tail J:180221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory