Smurf2^tm1Yez
Targeted Allele Detail

Summary

• Symbol: Smurf2^tm1Yez
• Name: SMAD specific E3 ubiquitin protein ligase 2; targeted mutation 1, Ying E Zhang
• MGI ID: MGI:5308952
• Gene: Smurf2 Location: Chr11:106710892-106811541 bp, - strand Genetic Position: Chr11, 70.03 cM, cytoband E1
• Alliance: Smurf2^tm1Yez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180221
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 9 and 10. The predicted protein lacks the last two WW domains and the HECT domain. Immunohistochemistry confirmed the inability of the protein product to either bind Smad3 or repress Smad3 transcriptional activity. (J:180221)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smurf2^tm1Yez

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smurf2 Mutation: 40 strains or lines available

References

• Original: J:180221 Tang LY, et al., Ablation of Smurf2 reveals an inhibition in TGF-beta signalling through multiple mono-ubiquitination of Smad3. EMBO J. 2011 Nov 30;30(23):4777-89
• All: 5 reference(s)