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P3h4 Gene Detail
Summary
  • Symbol
    P3h4
  • Name
    prolyl 3-hydroxylase family member 4 (non-enzymatic)
  • Synonyms
    1110036O03Rik, Leprel4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913430
    NCBI Gene: 66180
  • Gene Overview
    MyGene.info: P3H4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100408748-100414819 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913430
protein coding gene Chr11:100408456-100414836 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019153
protein coding gene Chr11:103166775-103173170 (-)
A/J MGP_AJ_G0019121
protein coding gene Chr11:98856250-98862639 (-)
AKR/J MGP_AKRJ_G0019090
protein coding gene Chr11:101903425-101909791 (-)
BALB/cJ MGP_BALBcJ_G0019095
protein coding gene Chr11:99336669-99343064 (-)
C3H/HeJ MGP_C3HHeJ_G0018904
protein coding gene Chr11:102100645-102107078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019544
protein coding gene Chr11:106372475-106378855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017170
protein coding gene Chr11:96273422-96280103 (-)
CAST/EiJ MGP_CASTEiJ_G0018458
protein coding gene Chr11:103071883-103078974 (-)
CBA/J MGP_CBAJ_G0018873
protein coding gene Chr11:110798568-110804963 (-)
DBA/2J MGP_DBA2J_G0018985
protein coding gene Chr11:98394898-98401293 (-)
FVB/NJ MGP_FVBNJ_G0018975
protein coding gene Chr11:97925779-97932485 (-)
LP/J MGP_LPJ_G0019054
protein coding gene Chr11:103710794-103717189 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019006
protein coding gene Chr11:110411139-110417517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019582
protein coding gene Chr11:102247447-102253842 (-)
PWK/PhJ MGP_PWKPhJ_G0018221
protein coding gene Chr11:99432045-99438482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018013
protein coding gene Chr11:101963763-101970200 (-)
WSB/EiJ MGP_WSBEiJ_G0018507
protein coding gene Chr11:102232200-102238586 (-)



Homology
more
  • Human Ortholog
    P3H4, prolyl 3-hydroxylase family member 4 (non-enzymatic)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    P3H4, prolyl 3-hydroxylase family member 4 (non-enzymatic)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LEPREL4, NO55, NOL55, SC65
  • Links
    NCBI Gene ID: 10609
    neXtProt AC: NX_Q92791
    UniProt: Q92791

  • Chr Location
    17q21.2; chr17:41801952-41812617 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4713
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: P3H4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased trabecular volume, compact bone thickness, skin tensile strength and muscle below the hypodermis with decreased cutaneous collagen fiber density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66180 NCBI Gene Model | MGI Sequence Detail 6072 C57BL/6J ±  kb
    transcript NM_176830 RefSeq | MGI Sequence Detail 1903 FVB/N  
    polypeptide Q8K2B0 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 52
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144143
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:251120 Klank RL, et al., Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level. Cell Rep. 2017 Jan 3;18(1):23-31

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory