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Ifitm3 Gene Detail
Summary
  • Symbol
    Ifitm3
  • Name
    interferon induced transmembrane protein 3
  • Synonyms
    1110004C05Rik, Fgls, fragilis, IP15, mil-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913391
    NCBI Gene: 66141
  • Gene Overview
    MyGene.info: IFITM3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141009590-141010744 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.25 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913391
protein coding gene Chr7:141009586-141010770 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033205
protein coding gene Chr7:146159754-146160938 (-)
A/J MGP_AJ_G0033187
protein coding gene Chr7:141997387-141998571 (-)
AKR/J MGP_AKRJ_G0033119
protein coding gene Chr7:145898762-145899952 (-)
BALB/cJ MGP_BALBcJ_G0033188
protein coding gene Chr7:141734547-141735731 (-)
C3H/HeJ MGP_C3HHeJ_G0032902
protein coding gene Chr7:145648605-145649789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033699
protein coding gene Chr7:151507517-151508701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030672
protein coding gene Chr7:143206823-143207992 (-)
CAST/EiJ MGP_CASTEiJ_G0032232
protein coding gene Chr7:137954097-137957510 (-)
CBA/J MGP_CBAJ_G0032874
protein coding gene Chr7:156620888-156622072 (-)
DBA/2J MGP_DBA2J_G0033027
protein coding gene Chr7:139945857-139947041 (-)
FVB/NJ MGP_FVBNJ_G0032979
protein coding gene Chr7:139847524-139848708 (-)
LP/J MGP_LPJ_G0033121
protein coding gene Chr7:147659982-147661166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033012
protein coding gene Chr7:157301135-157302319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033719
protein coding gene Chr7:144877554-144878738 (-)
PWK/PhJ MGP_PWKPhJ_G0031936
protein coding gene Chr7:133209806-133210987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031783
protein coding gene Chr7:131698568-131699760 (-)
WSB/EiJ MGP_WSBEiJ_G0032343
protein coding gene Chr7:145821211-145822401 (-)



Homology
more
  • Human Ortholog
    IFITM3, interferon induced transmembrane protein 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    IFITM3, interferon induced transmembrane protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1-8U, DSPA2b, IP15
  • Links
    NCBI Gene ID: 10410
    neXtProt AC: NX_Q01628
    UniProt: Q01628

  • Chr Location
    11p15.5; chr11:319673-320914 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IFITM3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66141 NCBI Gene Model | MGI Sequence Detail 1155 C57BL/6J ±  kb
transcript NM_025378 RefSeq | MGI Sequence Detail 648 C57BL/6  
polypeptide Q9CQW9 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007593 CD225/Dispanin family
Molecular
Reagents
less
  • All nucleic 169
    cDNA 162
    Primer pair 3
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 74
    Developmental Gene Expression 27
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:264160 Patoine A, et al., The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice. PLoS One. 2017;12(9):e0184568

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory