Tk2
Gene Detail

Symbol Name ID

Tk2 thymidine kinase 2, mitochondrial MGI:1913266

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:104226691-104248558 bp, - strand From NCBI annotation of GRCm38   21868 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxynucleoside kinase
Gene Tree: Tk2

Human homologs

Human Homolog		TK2, thymidine kinase 2, mitochondrial
NCBI Gene ID		7084
neXtProt AC		NX_O00142
Human Synonyms		MTDPS2, MTTK
Human Chr (Location)		16q22-q23.1; chr16:66541906-66584315 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TK2

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Knock-out mice die at 2-4 wks of age showing stunted growth, hypothermia, progressive mtDNA loss, aberrant myocardial fibers and altered adipose tissue structure. Knock-in mutant mice show encephalomyelopathy, impaired gait, mtDNA loss, altered mt dNTP pools and respiratory chain enzyme activities.

 
Human Diseases Modeled Using Mouse Tk2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	deoxycytidine metabolic process, deoxyribonucleotide metabolic process, ...
Component	mitochondrial inner membrane, mitochondrion
Function	ATP binding, deoxycytidine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) cDNA(55)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035824 (Evidence)
Entrez Gene	57813 (Evidence)
UniGene	183110
DFCI	TC1575455, TC1601204, TC1739060
DoTS	DT.101192660, DT.87069111, DT.96086102
NIA Mouse Gene Index	U030152
EC	2.7.1.21
Consensus CDS Project	CCDS22573.1
International Mouse Knockout Project Status	Tk2

Sequences

Length	Strain/Species
genomic	57813	NCBI Gene Model | MGI Sequence Detail	21868	C57BL/6J
transcript	NM_021028	RefSeq | MGI Sequence Detail	2400	C57BL/6
polypeptide	Q9R088	UniProt | EBI | MGI Sequence Detail	270	Not Applicable

All sequences(47) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002624	Deoxynucleoside kinase
Protein Ontology	PR:000016368	thymidine kinase 2, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:64961 Wettin K, et al., Cloning of mouse mitochondrial thymidine kinase 2 cDNA. FEBS Lett. 1999 Oct 22;460(1):103-6
(Latest) J:182328 Villarroya J, et al., Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice. PLoS One. 2011;6(12):e29691
All references(39)

Other accession IDs

MGI:2142713