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Tk2
Gene Detail
 Symbol
Name
ID
Tk2
thymidine kinase 2, mitochondrial
MGI:1913266
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:104226691-104248558 bp, - strand
From NCBI annotation of GRCm38

  21868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxynucleoside kinase
Gene Tree: Tk2

Human
homologs
Human Homolog TK2, thymidine kinase 2, mitochondrial
NCBI Gene ID 7084
neXtProt AC  NX_O00142
Human Synonyms  MTDPS2, MTTK
Human Chr (Location)  16q22-q23.1; chr16:66508003-66550412 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TK2
Alleles
and
phenotypes
All alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Knock-out mice die at 2-4 wks of age showing stunted growth, hypothermia, progressive mtDNA loss, aberrant myocardial fibers and altered adipose tissue structure. Knock-in mutant mice show encephalomyelopathy, impaired gait, mtDNA loss, altered mt dNTP pools and respiratory chain enzyme activities.
 
Human Diseases Modeled Using Mouse Tk2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process deoxycytidine metabolic process, deoxyribonucleoside monophosphate biosynthetic process, ...
Component mitochondrial inner membrane, mitochondrion
Function ATP binding, deoxycytidine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) cDNA(55)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035824 (Evidence)
Entrez Gene57813 (Evidence)
UniGene183110
DFCITC1575455, TC1601204, TC1739060
DoTSDT.101192660, DT.87069111, DT.96086102
NIA Mouse Gene IndexU030152
EC2.7.1.21
Consensus CDS ProjectCCDS22573.1
International Mouse Knockout Project StatusTk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57813 NCBI Gene Model | MGI Sequence Detail 21868 C57BL/6J ±  kb
transcript NM_021028 RefSeq | MGI Sequence Detail 2400 C57BL/6 
polypeptide Q9R088 UniProt | EBI | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002624 Deoxynucleoside kinase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000016368 thymidine kinase 2, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:64961 Wettin K, et al., Cloning of mouse mitochondrial thymidine kinase 2 cDNA. FEBS Lett. 1999 Oct 22;460(1):103-6
(Latest) J:200191 Zhou X, et al., Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect beta-oxidation. PLoS One. 2013;8(3):e58843
All references(42)
Other
accession IDs
MGI:2142713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory