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Carm1
Gene Detail
 Symbol
Name
ID
Carm1
coactivator-associated arginine methyltransferase 1
MGI:1913208
Synonyms Prmt4
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.82 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21546894-21589487 bp, + strand
From VEGA annotation of GRCm38

  42594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10990  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: type 1 arginine N-methyltransferase
Gene Tree: Carm1

Human
homologs
Human Homolog CARM1, coactivator-associated arginine methyltransferase 1
NCBI Gene ID 10498
neXtProt AC  NX_Q86X55
Human Synonyms  PRMT4
Human Chr (Location)  19p13.2; chr19:10871577-10923070 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(85) : Gene trapped(81) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null fetuses are small and die perinatally, whereas heterozygotes are born at the expected Mendelian ratio but show decreased survival through weaning. Mice homozygous for a kinase null allele exhibit neonatal lethality, arrested T cell development, and impaired adipogenesis.
 
Phenotype Images(1)
Interactions
Carm1 interacts with 364 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (108 annotations)
Process chromatin modification, endochondral bone morphogenesis, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (119)    Tissues (82)    Images (22)
Theiler Stages: 1, 2, 3, 15, 17, 19, 20, 21, 23, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 92
Northern blot 8
Western blot 7
RT-PCR 8
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020639 (Evidence)
Ensembl Gene ModelENSMUSG00000032185 (Evidence)
Entrez Gene59035 (Evidence)
NIA Mouse Gene IndexU010147
EC2.1.1.-, 2.1.1.125
PDB2V7E, 2V74
Consensus CDS ProjectCCDS22906.1, CCDS52736.1
International Mouse Knockout Project StatusCarm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020639 VEGA Gene Model | MGI Sequence Detail 42594 C57BL/6J ±  kb
transcript OTTMUST00000048895 VEGA | MGI Sequence Detail 3320 Not Applicable 
polypeptide OTTMUSP00000022541 VEGA | MGI Sequence Detail 651 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020989 Histone-arginine methyltransferase CARM1, N-terminal
InterPro IPR025799 Protein arginine N-methyltransferase
Protein Ontology PR:000005043 histone-arginine methyltransferase CARM1
References (Earliest) J:64957 Chen D, et al., Regulation of transcription by a protein methyltransferase. Science. 1999 Jun 25;284(5423):2174-7
(Latest) J:203762 Burton A, et al., Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory