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Trem2
Gene Detail
Symbol

Name
ID
Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150
Synonyms
Trem2a, Trem2b, Trem2c
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:48346401-48354147 bp, + strand
From VEGA annotation of GRCm38

  7747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10352  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TREM2
Gene Tree: Trem2

Human
homologs
TREM2, triggering receptor expressed on myeloid cells 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54209
neXtProt AC: NX_Q9NZC2

Human Synonyms: TREM-2, Trem2a, Trem2b, Trem2c

Human Chr (Location): 6p21.1; chr6:41158506-41163198 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TREM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele display enhanced cytokine production by macrophages in response to toll-like receptor agonists.
 
Interactions
Trem2 interacts with 57 markers (Mir16-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (84)    Tissues (33)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
Northern blot 10
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trem2    NEW 
Molecular
reagents
All nucleic(25) cDNA(24) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021045 (Evidence)
Ensembl Gene Model ENSMUSG00000023992 (Evidence)
Entrez Gene 83433 (Evidence)
UniGene 261623
DFCI TC1581874, TC1591116
DoTS DT.101353062, DT.99841612, DT.102555988, DT.101407724
NIA Mouse Gene Index U018077
Consensus CDS Project CCDS28865.1, CCDS70825.1
International Mouse Phenotyping Consortium Status Trem2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021045 VEGA Gene Model | MGI Sequence Detail 7747 C57BL/6J ±  kb
transcript OTTMUST00000049782 VEGA | MGI Sequence Detail 1056 Not Applicable 
polypeptide OTTMUSP00000023120 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000016626 triggering receptor expressed on myeloid cells 2
References
(Earliest) J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
(Latest) J:219850 Kawabori M, et al., Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015 Feb 25;35(8):3384-96
All references(50)
Other
accession IDs
MGI:1932924, MGI:1932925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory