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Trem2
Gene Detail
 Symbol
Name
ID
Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150
Synonyms Trem2a, Trem2b, Trem2c
Feature Type protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:48346401-48354147 bp, + strand
From VEGA annotation of GRCm38

  7747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10352  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Trem2

Human
homologs
Human Homolog TREM2, triggering receptor expressed on myeloid cells 2
NCBI Gene ID 54209
neXtProt AC  NX_Q9NZC2
Human Synonyms  TREM-2, Trem2a, Trem2b, Trem2c
Human Chr (Location)  6p21.1; chr6:41158506-41163186 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TREM2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display enhanced cytokine production by macrophages in response to toll-like receptor agonists.
 
Interactions
Trem2 interacts with 57 markers (Mir16-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cellular response to lipoteichoic acid, cellular response to peptidoglycan, ...
Component extracellular region, integral component of membrane, ...
Function lipopolysaccharide binding, lipoteichoic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (84)    Tissues (31)    Images (25)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 74
Northern blot 10
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(24) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021045 (Evidence)
Ensembl Gene ModelENSMUSG00000023992 (Evidence)
Entrez Gene83433 (Evidence)
UniGene261623
DFCITC1581874, TC1591116
DoTSDT.101353062, DT.101407724, DT.102555988, DT.99841612
NIA Mouse Gene IndexU018077
Consensus CDS ProjectCCDS28865.1, CCDS70825.1
International Mouse Knockout Project StatusTrem2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021045 VEGA Gene Model | MGI Sequence Detail 7747 C57BL/6J ±  kb
transcript OTTMUST00000049782 VEGA | MGI Sequence Detail 1056 Not Applicable 
polypeptide OTTMUSP00000023120 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000016626 triggering receptor expressed on myeloid cells 2
References (Earliest) J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
(Latest) J:202965 Goncalves LA, et al., TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19531-6
All references(49)
Other
accession IDs
MGI:1932924, MGI:1932925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory