Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of with a positive effect on social behavior. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and regulation of gene expression. Located in plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).