GO Annotations Graph

• Symbol: Trem2
• Name: triggering receptor expressed on myeloid cells 2
• ID: MGI:1913150

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0034186	apolipoprotein A-I binding	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:210929
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:191922
Molecular Function	GO:0071813	lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0070891	lipoteichoic acid binding	IDA	J:210929
Molecular Function	GO:0030169	low-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0042834	peptidoglycan binding	IDA	J:210929
Molecular Function	GO:0008429	phosphatidylethanolamine binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:277861
Molecular Function	GO:0005515	protein binding	IPI	J:183995
Molecular Function	GO:0005515	protein binding	IPI	J:191922
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:260524
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IMP	J:260524
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0120146	sulfatide binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISS	J:64954
Molecular Function	GO:0034189	very-low-density lipoprotein particle binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IMP	J:215678
Cellular Component	GO:0005886	plasma membrane	IDA	J:273534
Cellular Component	GO:0005886	plasma membrane	IMP	J:264653
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:264653
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:277170
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:285719
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:304709
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:96626
Biological Process	GO:0048143	astrocyte activation	IGI	J:256924
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:260524
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0071396	cellular response to lipid	ISO	J:164563
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IDA	J:210929
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0071224	cellular response to peptidoglycan	IDA	J:210929
Biological Process	GO:0150062	complement-mediated synapse pruning	IMP	J:273253
Biological Process	GO:0038160	CXCL12-activated CXCR4 signaling pathway	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IMP	J:266671
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:284724
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0097062	dendritic spine maintenance	IMP	J:285719
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:210929
Biological Process	GO:0070392	detection of lipoteichoic acid	IDA	J:210929
Biological Process	GO:0032499	detection of peptidoglycan	IDA	J:210929
Biological Process	GO:1905805	excitatory synapse pruning	IMP	J:272738
Biological Process	GO:0098657	import into cell	IGI	J:256924
Biological Process	GO:0045087	innate immune response	IC	J:210929
Biological Process	GO:0055088	lipid homeostasis	IMP	J:283590
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IC	J:210929
Biological Process	GO:0007613	memory	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	IMP	J:242830
Biological Process	GO:0001774	microglial cell activation	IMP	J:273509
Biological Process	GO:0001774	microglial cell activation	IMP	J:304584
Biological Process	GO:0001774	microglial cell activation	IGI	J:256924
Biological Process	GO:0001774	microglial cell activation	IGI	J:260524
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:266671
Biological Process	GO:0061518	microglial cell proliferation	IMP	J:274782
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	IMP	J:277170
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:273509
Biological Process	GO:0061889	negative regulation of astrocyte activation	IDA	J:305994
Biological Process	GO:1904093	negative regulation of autophagic cell death	IGI	J:242830
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:242830
Biological Process	GO:0010507	negative regulation of autophagy	IGI	J:242830
Biological Process	GO:0050866	negative regulation of cell activation	IDA	J:305994
Biological Process	GO:0010887	negative regulation of cholesterol storage	IMP	J:292426
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:284724
Biological Process	GO:0070345	negative regulation of fat cell proliferation	IMP	J:283590
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	IMP	J:304584
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:304584
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IMP	J:304584
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:273509
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	ISO	J:164563
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IMP	J:304709
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IMP	J:304588
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	ISO	J:164563
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IDA	J:305994
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	IMP	J:284724
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	IMP	J:304588
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:304584
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	IMP	J:292426
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	IMP	J:304709
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IMP	J:304709
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	IDA	J:305994
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:273509
Biological Process	GO:0150076	neuroinflammatory response	IMP	J:264653
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:164563
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:178250
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:215678
Biological Process	GO:0006911	phagocytosis, engulfment	IDA	J:144335
Biological Process	GO:0006910	phagocytosis, recognition	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:277170
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:281622
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:281247
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:242830
Biological Process	GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	ISO	J:164563
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	IMP	J:242830
Biological Process	GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway	ISO	J:164563
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IBA	J:265628
Biological Process	GO:1905291	positive regulation of CAMKK-AMPK signaling cascade	IGI	J:242830
Biological Process	GO:2000350	positive regulation of CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	IGI	J:243588
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:292426
Biological Process	GO:0045960	positive regulation of complement activation, classical pathway	IMP	J:273253
Biological Process	GO:1901076	positive regulation of engulfment of apoptotic cell	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:273509
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:1904951	positive regulation of establishment of protein localization	IMP	J:277170
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:256924
Biological Process	GO:0010983	positive regulation of high-density lipoprotein particle clearance	IMP	J:283590
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:273509
Biological Process	GO:1901980	positive regulation of inward rectifier potassium channel activity	IMP	J:260524
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	IMP	J:283590
Biological Process	GO:0034241	positive regulation of macrophage fusion	IMP	J:258167
Biological Process	GO:1903980	positive regulation of microglial cell activation	IDA	J:284720
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:215678
Biological Process	GO:1903980	positive regulation of microglial cell activation	ISO	J:164563
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:277170
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:274782
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:272738
Biological Process	GO:1903980	positive regulation of microglial cell activation	IBA	J:265628
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:243588
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:277170
Biological Process	GO:1904141	positive regulation of microglial cell migration	IGI	J:260524
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:164563
Biological Process	GO:1904141	positive regulation of microglial cell migration	IGI	J:243588
Biological Process	GO:1904141	positive regulation of microglial cell migration	IMP	J:266671
Biological Process	GO:0010822	positive regulation of mitochondrion organization	IMP	J:242830
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	IMP	J:274782
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:273509
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IMP	J:273549
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:292426
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:284720
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:284720
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:304584
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:272738
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:274782
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP	J:305995
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	IMP	J:260524
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IGI	J:260524
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:1905808	positive regulation of synapse pruning	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	IGI	J:242830
Biological Process	GO:0070269	pyroptosis	IMP	J:284724
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	IMP	J:304584
Biological Process	GO:0010468	regulation of gene expression	IMP	J:273253
Biological Process	GO:0010468	regulation of gene expression	IGI	J:260524
Biological Process	GO:0110089	regulation of hippocampal neuron apoptotic process	IMP	J:305995
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:273253
Biological Process	GO:0032675	regulation of interleukin-6 production	IGI	J:260524
Biological Process	GO:1902531	regulation of intracellular signal transduction	IGI	J:260524
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0071640	regulation of macrophage inflammatory protein 1 alpha production	IGI	J:260524
Biological Process	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:305995
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IGI	J:260524
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IBA	J:265628
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	ISO	J:164563
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IMP	J:266671
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IMP	J:243588
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization	IBA	J:265628
Biological Process	GO:0060075	regulation of resting membrane potential	IMP	J:260524
Biological Process	GO:0034151	regulation of toll-like receptor 6 signaling pathway	IMP	J:304709
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:242830
Biological Process	GO:0045728	respiratory burst after phagocytosis	IMP	J:273253
Biological Process	GO:0048678	response to axon injury	IMP	J:281622
Biological Process	GO:0048678	response to axon injury	ISO	J:164563
Biological Process	GO:0048678	response to axon injury	IMP	J:292426
Biological Process	GO:0002931	response to ischemia	IMP	J:273509
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0035176	social behavior	IMP	J:272738