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Pias1 Gene Detail
Summary
  • Symbol
    Pias1
  • Name
    protein inhibitor of activated STAT 1
  • Synonyms
    2900068C24Rik, Ddxbp1, GBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913125
    NCBI Gene: 56469
  • Gene Overview
    MyGene.info: PIAS1
Location & Maps
more
  • Sequence Map
    Chr9:62880077-62980879 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100803 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 33.91 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIAS1, protein inhibitor of activated STAT 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIAS1, protein inhibitor of activated STAT 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DDXBP1, GBP, GU/RH-II, ZMIZ3
  • Links
    NCBI Gene ID: 8554
    neXtProt AC: NX_O75925

  • Chr Location
    15q; chr15:68054234-68191459 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Targeted
    2
  • Genomic Mutations
    1 involving Pias1
  • Incidental Mutations
Homozygous null mice display partial perinatal lethality, reduced body size, decreased susceptibility to viral infection, and increased susceptibility to bacterial infection and LPS-induced endotoxin shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032405 Ensembl Gene Model | MGI Sequence Detail 100803 C57BL/6J ±  kb
transcript ENSMUST00000098651 Ensembl | MGI Sequence Detail 3855 Not Applicable  
polypeptide ENSMUSP00000096248 Ensembl | MGI Sequence Detail 651 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    cDNA 16
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1920216
References
more
  • Summaries
    All 63
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 14
  • Earliest
    J:55317 Liu B, et al., Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626-31
  • Latest
    J:209129 Beketaev I, et al., Potentiation of Tbx5-mediated transactivation by SUMO conjugation and protein inhibitor of activated STAT 1 (PIAS1). Int J Biochem Cell Biol. 2014 May;50:82-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory