Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including SUMO ligase activity; transcription cis-regulatory region binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nuclear periphery. Colocalizes with PML body. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; trunk mesenchyme; and urinary system. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1).