Plag1
Gene Detail

Symbol Name ID

Plag1 pleiomorphic adenoma gene 1 MGI:1891916

Feature Type

protein coding gene

Genetic Map

Chromosome 4

2.18 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:3900996-3938423 bp, - strand From VEGA annotation of GRCm38   37428 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Plag1

Human homologs

Human Homolog		PLAG1, pleiomorphic adenoma gene 1
NCBI Gene ID		5324
neXtProt AC		NX_Q6DJT9
Human Synonyms		PSA, SGPA, ZNF912
Human Chr (Location)		8q12; chr8:57073468-57123859 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLAG1

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	gland morphogenesis, induction of apoptosis, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (167)    Tissues (143)    Images (6)
Theiler Stages: 2, 3, 4, 5, 17, 18, 21, 22, 23, 28

Assay Type	Results
RNA in situ	147
RT-PCR	20

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000004402 (Evidence)
Ensembl Gene Model	ENSMUSG00000003282 (Evidence)
Entrez Gene	56711 (Evidence)
UniGene	331467
DFCI	TC1593225, TC1613152, TC1624144, TC1678206
DoTS	DT.110782685, DT.91567825, DT.94165428, DT.97346087
NIA Mouse Gene Index	U024808
Consensus CDS Project	CCDS17941.1
International Mouse Knockout Project Status	Plag1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004402	VEGA Gene Model | MGI Sequence Detail	37428	C57BL/6J
transcript	OTTMUST00000009975	VEGA | MGI Sequence Detail	4774	Not Applicable
polypeptide	OTTMUSP00000004778	VEGA | MGI Sequence Detail	499	Not Applicable

All sequences(41) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(167 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000012822	zinc finger protein PLAG1

References

(Earliest) J:64937 Kas K, et al., Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [published erratum appears in Nat Genet 1997 Apr;15(4):411]. Nat Genet. 1997 Feb;15(2):170-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)