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Plag1 Gene Detail
Summary
  • Symbol
    Plag1
  • Name
    pleiomorphic adenoma gene 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891916
    NCBI Gene: 56711
  • Gene Overview
    MyGene.info: PLAG1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3900996-3938423 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 2.18 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891916
protein coding gene Chr4:3898769-3938435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028026
protein coding gene Chr4:390733-428269 (-)
A/J MGP_AJ_G0027984
protein coding gene Chr4:458765-501029 (-)
AKR/J MGP_AKRJ_G0027950
protein coding gene Chr4:401587-440395 (-)
BALB/cJ MGP_BALBcJ_G0027996
protein coding gene Chr4:432140-469570 (-)
C3H/HeJ MGP_C3HHeJ_G0027726
protein coding gene Chr4:562594-600257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028439
protein coding gene Chr4:552049-592332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025783
protein coding gene Chr4:403932-443096 (-)
CAST/EiJ MGP_CASTEiJ_G0027179
protein coding gene Chr4:473061-514785 (-)
CBA/J MGP_CBAJ_G0027701
protein coding gene Chr4:426453-469856 (-)
DBA/2J MGP_DBA2J_G0027841
protein coding gene Chr4:429804-467206 (-)
FVB/NJ MGP_FVBNJ_G0027808
protein coding gene Chr4:359383-396633 (-)
LP/J MGP_LPJ_G0027952
protein coding gene Chr4:437507-476477 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027841
protein coding gene Chr4:609830-650716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028498
protein coding gene Chr4:398419-436532 (-)
PWK/PhJ MGP_PWKPhJ_G0026901
protein coding gene Chr4:491391-532553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026731
protein coding gene Chr4:424208-462268 (-)
WSB/EiJ MGP_WSBEiJ_G0027259
protein coding gene Chr4:544295-582431 (-)



Homology
more
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PSA, SGPA, ZNF912
  • Links
    NCBI Gene ID: 5324
    neXtProt AC: NX_Q6DJT9
    UniProt: Q6DJT9

  • Chr Location
    8q12.1; chr8:56160909-56211327 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1993
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLAG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PLAG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003282 Ensembl Gene Model | MGI Sequence Detail 37428 C57BL/6J ±  kb
    transcript ENSMUST00000003369 Ensembl | MGI Sequence Detail 4774 Not Applicable  
    polypeptide ENSMUSP00000003369 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:64937 Kas K, et al., Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [published erratum appears in Nat Genet 1997 Apr;15(4):411]. Nat Genet. 1997 Feb;15(2):170-4
    • Latest
      J:247603 Juma AR, et al., PLAG1 deficiency impairs spermatogenesis and sperm motility in mice. Sci Rep. 2017 Jul 13;7(1):5317

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory