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Plag1
Gene Detail
Symbol

Name
ID
Plag1
pleiomorphic adenoma gene 1
MGI:1891916
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.18 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:3900996-3938423 bp, - strand
From VEGA annotation of GRCm38

  37428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLAG1
Gene Tree: Plag1

Human
homologs
PLAG1, pleiomorphic adenoma gene 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5324
neXtProt AC: NX_Q6DJT9

Human Synonyms: PSA, SGPA, ZNF912

Human Chr (Location): 8q12; chr8:56160909-56211314 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLAG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.
 
Interactions
Plag1 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process gland morphogenesis, multicellular organism growth, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (251)    Tissues (195)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 238
RT-PCR 13
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004402 (Evidence)
Ensembl Gene Model ENSMUSG00000003282 (Evidence)
Entrez Gene 56711 (Evidence)
UniGene 331467
DFCI TC1593225, TC1613152, TC1624144, TC1678206
DoTS DT.110782685, DT.91567825, DT.94165428, DT.97346087
NIA Mouse Gene Index U024808
Consensus CDS Project CCDS17941.1
International Mouse Phenotyping Consortium Status Plag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004402 VEGA Gene Model | MGI Sequence Detail 37428 C57BL/6J ±  kb
transcript OTTMUST00000009975 VEGA | MGI Sequence Detail 4774 Not Applicable 
polypeptide OTTMUSP00000004778 VEGA | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000012822 zinc finger protein PLAG1
References
(Earliest) J:64937 Kas K, et al., Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [published erratum appears in Nat Genet 1997 Apr;15(4):411]. Nat Genet. 1997 Feb;15(2):170-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory