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Becn1
Gene Detail
Symbol

Name
ID
Becn1
beclin 1, autophagy related
MGI:1891828
Synonyms
Atg6, MGC:6843
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.58 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101285952-101302286 bp, - strand
From VEGA annotation of GRCm38

  16335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2794  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BECN1
Gene Tree: Becn1

Human
homologs
BECN1, beclin 1, autophagy related
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8678
neXtProt AC: NX_Q14457

Human Synonyms: ATG6, beclin1, VPS30

Human Chr (Location): 17q21; chr17:42810132-42824292 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(3) Targeted(9)
Genomic Mutations involving Becn1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy.
 
Phenotype Images(1)
Interactions
Becn1 interacts with 374 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (51)    Tissues (30)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 37
Western blot 1
RT-PCR 9
cDNA source data(6)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase becn1 ; ZFIN becn1    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000002791 (Evidence)
Ensembl Gene Model ENSMUSG00000035086 (Evidence)
Entrez Gene 56208 (Evidence)
PDB 3BL2
Consensus CDS Project CCDS25462.1
International Mouse Phenotyping Consortium Status Becn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002791 VEGA Gene Model | MGI Sequence Detail 16335 C57BL/6J ±  kb
transcript OTTMUST00000005620 VEGA | MGI Sequence Detail 4365 Not Applicable 
polypeptide OTTMUSP00000002689 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007243 Atg6/Beclin
InterPro IPR029318 Beclin-1, BH3 domain
Protein Ontology PR:000004719 beclin-1
References
(Earliest) J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
(Latest) J:216461 Gawriluk TR, et al., Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4194-203
All references(97)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory