Becn1
Gene Detail

Symbol Name ID

Becn1 beclin 1, autophagy related MGI:1891828

Synonyms

Atg6, MGC:6843

Feature Type

protein coding gene

Genetic Map

Chromosome 11

64.58 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:101285952-101302286 bp, - strand From VEGA annotation of GRCm38   16335 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2794  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Becn1

Human homologs

Human Homolog		BECN1, beclin 1, autophagy related
NCBI Gene ID		8678
neXtProt AC		NX_Q14457
Human Synonyms		ATG6, beclin1, VPS30
Human Chr (Location)		17q21; chr17:40962150-40976310 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(6) Gene trapped(3)
 

Haploinsufficiency of this locus results in increased tumorigenesis.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function	protein binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (42)    Tissues (27)    Images (15)
Theiler Stages: 9, 11, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	37
Western blot	1

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000002791 (Evidence)
Ensembl Gene Model	ENSMUSG00000035086 (Evidence)
Entrez Gene	56208 (Evidence)
PDB	3BL2
Consensus CDS Project	CCDS25462.1
International Mouse Knockout Project Status	Becn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002791	VEGA Gene Model | MGI Sequence Detail	16335	C57BL/6J
transcript	OTTMUST00000005620	VEGA | MGI Sequence Detail	4365	Not Applicable
polypeptide	OTTMUSP00000002689	VEGA | MGI Sequence Detail	448	Not Applicable

All sequences(80) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007243	Beclin family
Protein Ontology	PR:000004719	beclin-1

References

(Earliest) J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
(Latest) J:195814 Hariharan N, et al., Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One. 2013;8(1):e51632
All references(77)