About   Help   FAQ
Becn1 Gene Detail
Summary
  • Symbol
    Becn1
  • Name
    beclin 1, autophagy related
  • Synonyms
    Atg6, MGC:6843
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891828
    NCBI Gene: 56208
  • Gene Overview
    MyGene.info: BECN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:101285952-101302286 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16335 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.58 cM, cytoband D
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BECN1, beclin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BECN1, beclin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATG6, beclin1, VPS30
  • Links
    NCBI Gene ID: 8678
    neXtProt AC: NX_Q14457
    UniProt: Q14457

  • Chr Location
    17q21.31; chr17:42810132-42824316 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2794
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BECN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002791 VEGA Gene Model | MGI Sequence Detail 16335 C57BL/6J ±  kb
    transcript OTTMUST00000005620 VEGA | MGI Sequence Detail 4365 Not Applicable  
    polypeptide OTTMUSP00000002689 VEGA | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      163 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 16
      Gene Ontology 26
      Phenotypes 71
    • Earliest
      J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
    • Latest
      J:263126 Lu Y, et al., Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge. Sci Rep. 2018 May 29;8(1):8251

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory