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Becn1
Gene Detail
 Symbol
Name
ID
Becn1
beclin 1, autophagy related
MGI:1891828
Synonyms Atg6, MGC:6843
Feature Type protein coding gene
Genetic Map
Chromosome 11
64.58 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101285952-101302286 bp, - strand
From VEGA annotation of GRCm38

  16335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2794  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Becn1

Human
homologs
Human Homolog BECN1, beclin 1, autophagy related
NCBI Gene ID 8678
neXtProt AC  NX_Q14457
Human Synonyms  ATG6, beclin1, VPS30
Human Chr (Location)  17q21; chr17:42810132-42824292 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy.
 
Phenotype Images(1)
Interactions
Becn1 interacts with 375 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (42)    Tissues (27)    Images (15)
Theiler Stages: 9, 11, 23, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 37
Western blot 1
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000002791 (Evidence)
Ensembl Gene ModelENSMUSG00000035086 (Evidence)
Entrez Gene56208 (Evidence)
PDB3BL2
Consensus CDS ProjectCCDS25462.1
International Mouse Knockout Project StatusBecn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002791 VEGA Gene Model | MGI Sequence Detail 16335 C57BL/6J ±  kb
transcript OTTMUST00000005620 VEGA | MGI Sequence Detail 4365 Not Applicable 
polypeptide OTTMUSP00000002689 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007243 Beclin family
Protein Ontology PR:000004719 beclin-1
References (Earliest) J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
(Latest) J:207774 Lam HC, et al., Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013 Dec 2;123(12):5212-30
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory