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Becn1 Gene Detail
Summary
  • Symbol
    Becn1
  • Name
    beclin 1, autophagy related
  • Synonyms
    Atg6, MGC:6843
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891828
    NCBI Gene: 56208
  • Gene Overview
    MyGene.info: BECN1
Location & Maps
more
  • Sequence Map
    Chr11:101285952-101302286 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16335 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.58 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BECN1, beclin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BECN1, beclin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATG6, beclin1, VPS30
  • Links
    NCBI Gene ID: 8678
    neXtProt AC: NX_Q14457

  • Chr Location
    17q21; chr17:42810132-42824292 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2794
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BECN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 5 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    3
  • Targeted
    9
  • Genomic Mutations
    1 involving Becn1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002791 VEGA Gene Model | MGI Sequence Detail 16335 C57BL/6J ±  kb
transcript OTTMUST00000005620 VEGA | MGI Sequence Detail 4365 Not Applicable  
polypeptide OTTMUSP00000002689 VEGA | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    163 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 7
References
more
  • Summaries
    All 111
    Developmental Gene Expression 10
    Gene Ontology 23
    Phenotypes 54
  • Earliest
    J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
  • Latest
    J:226428 Ouseph MM, et al., Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood. 2015 Sep 3;126(10):1224-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory